EC number:3.1.3.57
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.1 Acting on ester bonds |
| 3.1.3 Phosphoric-monoester hydrolases |
| ID: | 3.1.3.57 | ||
|---|---|---|---|
| Description: | Inositol-1,4-bisphosphate 1-phosphatase. | ||
| Alternative Name: |
Inositol polyphosphate 1-phosphatase. | ||
| Prosite: | PDOC00547; | ||
| PDB: |
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| Cath: | 3.30.540.10; 4.10.460.10; 3.40.190.80; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.3.57 |
| BRENDA Enzyme Link: | BRENDA 3.1.3.57 |
| KEGG Enzyme Link: | KEGG3.1.3.57 |
| BioCyc Enzyme Link: | BioCyc 3.1.3.57 |
| ExPASy Enzyme Link: | ExPASy3.1.3.57 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.3.57 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.3.57 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.3.57 |
| IntEnz Enzyme Link: | IntEnz 3.1.3.57 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.3.57 |
| RHEA:15553 | 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structure of inositol polyphosphate 1-phosphatase at 2.3-A resolution. | York JD, Ponder JW, Chen ZW, Mathews FS, Majerus PW | 1994 Nov 15 | 7947723 |
| Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. | Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF | 1983 May 15 | 6309146 |
| The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes. | Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW | 1987 Feb 15 | 3029066 |
| Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+. | Inhorn RC, Majerus PW | 1987 Nov 25 | 2824473 |
| Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy. | Patel S, Yenush L, Rodríguez PL, Serrano R, Blundell TL | 2002 Jan 25 | 11812139 |