EC number:3.1.3.64
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.1 Acting on ester bonds |
| 3.1.3 Phosphoric-monoester hydrolases |
| ID: | 3.1.3.64 |
|---|---|
| Description: | Phosphatidylinositol-3-phosphatase. |
| Alternative Name: |
Phosphatidyl-3-phosphate 3-phosphohydrolase. Inositol-polyphosphate 3-phosphatase. Inositol-1,3-bisphosphate 3-phosphatase. Inositol 1,3-bisphosphate phosphatase. D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase. |
| Cath: | 2.30.29.30; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.3.64 |
| BRENDA Enzyme Link: | BRENDA 3.1.3.64 |
| KEGG Enzyme Link: | KEGG3.1.3.64 |
| BioCyc Enzyme Link: | BioCyc 3.1.3.64 |
| ExPASy Enzyme Link: | ExPASy3.1.3.64 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.3.64 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.3.64 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.3.64 |
| IntEnz Enzyme Link: | IntEnz 3.1.3.64 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.3.64 |
| RHEA:12316 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Divergent functions of the myotubularin (MTM) homologs AtMTM1 and AtMTM2 in Arabidopsis thaliana: evolution of the plant MTM family. | Ding Y, Ndamukong I, Zhao Y, Xia Y, Riethoven JJ, Jones DR, Divecha N, Avramova Z | 2012 Jun | 22324391 |
| Phosphatidylinositol 5-phosphate links dehydration stress to the activity of ARABIDOPSIS TRITHORAX-LIKE factor ATX1. | Ndamukong I, Jones DR, Lapko H, Divecha N, Avramova Z | 2010 Oct 13 | 20967218 |
| The Arabidopsis chromatin modifier ATX1, the myotubularin-like AtMTM and the response to drought. | Ding Y, Lapko H, Ndamukong I, Xia Y, Al-Abdallat A, Lalithambika S, Sadder M, Saleh A, Fromm M, Riethoven JJ, Lu G, Avramova Z | 2009 Nov | 19901554 |
| Characterization and functional studies of a FYVE domain-containing phosphatase in C. elegans. | Ma J, Zeng F, Ho WT, Teng L, Li Q, Fu X, Zhao ZJ | 2008 Aug 1 | 18393358 |
| Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP. | Nandurkar HH, Layton M, Laporte J, Selan C, Corcoran L, Caldwell KK, Mochizuki Y, Majerus PW, Mitchell CA | 2003 Jul 22 | 12847286 |
| Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase. | Kim SA, Vacratsis PO, Firestein R, Cleary ML, Dixon JE | 2003 Apr 15 | 12668758 |
| Muscle-specific alternative splicing of myotubularin-related 1 gene is impaired in DM1 muscle cells. | Buj-Bello A, Furling D, Tronchère H, Laporte J, Lerouge T, Butler-Browne GS, Mandel JL | 2002 Sep 15 | 12217958 |
| Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1. | Berger P, Bonneick S, Willi S, Wymann M, Suter U | 2002 Jun 15 | 12045210 |
| Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease. | Kim SA, Taylor GS, Torgersen KM, Dixon JE | 2002 Feb 8 | 11733541 |
| Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity. | Walker DM, Urbé S, Dove SK, Tenza D, Raposo G, Clague MJ | 2001 Oct 16 | 11676921 |
| Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway. | Blondeau F, Laporte J, Bodin S, Superti-Furga G, Payrastre B, Mandel JL | 2000 Sep 22 | 11001925 |
| Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate. | Taylor GS, Maehama T, Dixon JE | 2000 Aug 1 | 10900271 |
| SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases. | Hughes WE, Woscholski R, Cooke FT, Patrick RS, Dove SK, McDonald NQ, Parker PJ | 2000 Jan 14 | 10625610 |
| Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. | Mochizuki Y, Majerus PW | 2003 Aug 19 | 12890864 |