EC number:3.1.3.66
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.1 Acting on ester bonds |
| 3.1.3 Phosphoric-monoester hydrolases |
| ID: | 3.1.3.66 |
|---|---|
| Description: | Phosphatidylinositol-3,4-bisphosphate 4-phosphatase. |
| Alternative Name: |
Phosphoinositide 4-phosphatase. Inositol-3,4-bisphosphate 4-phosphatase. Inositol polyphosphate 4-phosphatase type II. Inositol polyphosphate 4-phosphatase. D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.3.66 |
| BRENDA Enzyme Link: | BRENDA 3.1.3.66 |
| KEGG Enzyme Link: | KEGG3.1.3.66 |
| BioCyc Enzyme Link: | BioCyc 3.1.3.66 |
| ExPASy Enzyme Link: | ExPASy3.1.3.66 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.3.66 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.3.66 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.3.66 |
| IntEnz Enzyme Link: | IntEnz 3.1.3.66 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.3.66 |
| RHEA:17193 | 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 3-phosphate) + phosphate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. | Norris FA, Atkins RC, Majerus PW | 1997 Sep 19 | 9295334 |
| The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase. | Norris FA, Auethavekiat V, Majerus PW | 1995 Jul 7 | 7608176 |
| Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities. | Lopez SM, Hodgson MC, Packianathan C, Bingol-Ozakpinar O, Uras F, Rosen BP, Agoulnik IU | 2013 Oct 18 | 24070612 |
| The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. | Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T | 2010 May 27 | 20463662 |