EC number:3.1.3.67
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.1 Acting on ester bonds |
| 3.1.3 Phosphoric-monoester hydrolases |
| ID: | 3.1.3.67 |
|---|---|
| Description: | Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. |
| Alternative Name: |
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase. |
| Cath: | 3.90.190.10; 2.60.40.1110; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.3.67 |
| BRENDA Enzyme Link: | BRENDA 3.1.3.67 |
| KEGG Enzyme Link: | KEGG3.1.3.67 |
| BioCyc Enzyme Link: | BioCyc 3.1.3.67 |
| ExPASy Enzyme Link: | ExPASy3.1.3.67 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.3.67 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.3.67 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.3.67 |
| IntEnz Enzyme Link: | IntEnz 3.1.3.67 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.3.67 |
| RHEA:25017 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. | Maehama T, Dixon JE | 1998 May 29 | 9593664 |
| TPIP: a novel phosphoinositide 3-phosphatase. | Walker SM, Downes CP, Leslie NR | 2001 Dec 1 | 11716755 |