EC number:3.1.3.73
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.1 Acting on ester bonds |
| 3.1.3 Phosphoric-monoester hydrolases |
| ID: | 3.1.3.73 |
|---|---|
| Description: | Adenosylcobalamin/alpha-ribazole phosphatase. |
| Alternative Name: |
Alpha-ribazole phosphatase. Adenosylcobalamin phosphatase. |
| Cath: | 1.10.1610.10; 3.90.550.10; 3.40.50.10210; 3.40.50.1240; 3.40.50.300; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.3.73 |
| BRENDA Enzyme Link: | BRENDA 3.1.3.73 |
| KEGG Enzyme Link: | KEGG3.1.3.73 |
| BioCyc Enzyme Link: | BioCyc 3.1.3.73 |
| ExPASy Enzyme Link: | ExPASy3.1.3.73 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.3.73 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.3.73 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.3.73 |
| IntEnz Enzyme Link: | IntEnz 3.1.3.73 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.3.73 |
| RHEA:30367 | adenosylcob(III)alamin 5'-phosphate + H2O = adenosylcob(III)alamin + phosphate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The biosynthesis of adenosylcobalamin (vitamin B12). | Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC | 2002 Aug | 12195810 |
| The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin. | O'Toole GA, Trzebiatowski JR, Escalante-Semerena JC | 1994 Oct 21 | 7929373 |
| Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5'-phosphate by the CobC phosphatase is the last step of the pathway. | Zayas CL, Escalante-Semerena JC | 2007 Mar | 17209023 |
| RHEA:24456 | alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin. | O'Toole GA, Trzebiatowski JR, Escalante-Semerena JC | 1994 Oct 21 | 7929373 |
| Structural and functional characterization of an RNase HI domain from the bifunctional protein Rv2228c from Mycobacterium tuberculosis. | Watkins HA, Baker EN | 2010 Jun | 20363939 |
| Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5'-phosphate by the CobC phosphatase is the last step of the pathway. | Zayas CL, Escalante-Semerena JC | 2007 Mar | 17209023 |