EC number:3.1.3.75
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.1 Acting on ester bonds |
| 3.1.3 Phosphoric-monoester hydrolases |
| ID: | 3.1.3.75 |
|---|---|
| Description: | Phosphoethanolamine/phosphocholine phosphatase. |
| Alternative Name: |
PHOSPHO1. 3X11A. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.3.75 |
| BRENDA Enzyme Link: | BRENDA 3.1.3.75 |
| KEGG Enzyme Link: | KEGG3.1.3.75 |
| BioCyc Enzyme Link: | BioCyc 3.1.3.75 |
| ExPASy Enzyme Link: | ExPASy3.1.3.75 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.3.75 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.3.75 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.3.75 |
| IntEnz Enzyme Link: | IntEnz 3.1.3.75 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.3.75 |
| RHEA:16089 | H2O + phosphoethanolamine = ethanolamine + phosphate |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification and cloning of a novel phosphatase expressed at high levels in differentiating growth plate chondrocytes. | Houston B, Seawright E, Jefferies D, Hoogland E, Lester D, Whitehead C, Farquharson C | 1999 Jan 11 | 9990301 |
| Phosphorylcholine Phosphatase: A Peculiar Enzyme of Pseudomonas aeruginosa. | Domenech CE, Otero LH, Beassoni PR, Lisa AT | 2011 | 21915373 |
| Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2. | Roberts SJ, Stewart AJ, Schmid R, Blindauer CA, Bond SR, Sadler PJ, Farquharson C | 2005 Aug 31 | 16054448 |
| Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities. | Roberts SJ, Stewart AJ, Sadler PJ, Farquharson C | 2004 Aug 15 | 15175005 |
| Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily. | Stewart AJ, Schmid R, Blindauer CA, Paisey SJ, Farquharson C | 2003 Dec | 14983068 |
| RHEA:10492 | H2O + phosphocholine = choline + phosphate |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification and cloning of a novel phosphatase expressed at high levels in differentiating growth plate chondrocytes. | Houston B, Seawright E, Jefferies D, Hoogland E, Lester D, Whitehead C, Farquharson C | 1999 Jan 11 | 9990301 |
| Phosphorylcholine Phosphatase: A Peculiar Enzyme of Pseudomonas aeruginosa. | Domenech CE, Otero LH, Beassoni PR, Lisa AT | 2011 | 21915373 |
| Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2. | Roberts SJ, Stewart AJ, Schmid R, Blindauer CA, Bond SR, Sadler PJ, Farquharson C | 2005 Aug 31 | 16054448 |
| Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities. | Roberts SJ, Stewart AJ, Sadler PJ, Farquharson C | 2004 Aug 15 | 15175005 |
| Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily. | Stewart AJ, Schmid R, Blindauer CA, Paisey SJ, Farquharson C | 2003 Dec | 14983068 |