EC number:3.1.3.76
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.1 Acting on ester bonds |
| 3.1.3 Phosphoric-monoester hydrolases |
| ID: | 3.1.3.76 |
|---|---|
| Description: | Lipid-phosphate phosphatase. |
| Alternative Name: |
Soluble epoxide hydrolase. Hydroxy lipid phosphatase. Hydroxy fatty acid phosphatase. Dihydroxy fatty acid phosphatase. |
| Cath: | 1.10.150.240; 3.10.450.50; 3.40.50.1000; 3.40.50.1820; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.3.76 |
| BRENDA Enzyme Link: | BRENDA 3.1.3.76 |
| KEGG Enzyme Link: | KEGG3.1.3.76 |
| BioCyc Enzyme Link: | BioCyc 3.1.3.76 |
| ExPASy Enzyme Link: | ExPASy3.1.3.76 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.3.76 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.3.76 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.3.76 |
| IntEnz Enzyme Link: | IntEnz 3.1.3.76 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.3.76 |
| RHEA:16537 | (9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase. | Tran KL, Aronov PA, Tanaka H, Newman JW, Hammock BD, Morisseau C | 2005 Sep 13 | 16142916 |
| Polymorphisms in human soluble epoxide hydrolase: effects on enzyme activity, enzyme stability, and quaternary structure. | Srivastava PK, Sharma VK, Kalonia DS, Grant DF | 2004 Jul 15 | 15196990 |
| Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis. | Gomez GA, Morisseau C, Hammock BD, Christianson DW | 2004 Apr 27 | 15096040 |
| The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. | Newman JW, Morisseau C, Harris TR, Hammock BD | 2003 Feb 18 | 12574510 |
| The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase. | Cronin A, Mowbray S, Dürk H, Homburg S, Fleming I, Fisslthaler B, Oesch F, Arand M | 2003 Feb 18 | 12574508 |
| Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase. | Argiriadi MA, Morisseau C, Hammock BD, Christianson DW | 1999 Sep 14 | 10485878 |
| Epoxide hydrolases: their roles and interactions with lipid metabolism. | Newman JW, Morisseau C, Hammock BD | 2005 Jan | 15748653 |