EC number:3.1.3.78
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.1 Acting on ester bonds |
| 3.1.3 Phosphoric-monoester hydrolases |
| ID: | 3.1.3.78 |
|---|---|
| Description: | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase. |
| Alternative Name: |
PtdIns-4,5-P(2) 4-phosphatase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.3.78 |
| BRENDA Enzyme Link: | BRENDA 3.1.3.78 |
| KEGG Enzyme Link: | KEGG3.1.3.78 |
| BioCyc Enzyme Link: | BioCyc 3.1.3.78 |
| ExPASy Enzyme Link: | ExPASy3.1.3.78 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.3.78 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.3.78 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.3.78 |
| IntEnz Enzyme Link: | IntEnz 3.1.3.78 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.3.78 |
| RHEA:25674 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis. | Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW | 2007 Oct 23 | 17940011 |
| Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase. | Mason D, Mallo GV, Terebiznik MR, Payrastre B, Finlay BB, Brumell JH, Rameh L, Grinstein S | 2007 Apr | 17389247 |
| The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases. | Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW | 2005 Dec 27 | 16365287 |
| Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology. | Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B | 2002 Oct 1 | 12356723 |