Enzyme

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     3. Hydrolases
        3.1 Acting on ester bonds
            3.1.3 Phosphoric-monoester hydrolases
ID:3.1.3.86
Description:Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase.
Alternative Name: SHIP.
Cath: 1.10.150.50; 3.30.505.10; 3.60.10.10;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 3.1.3.86
BRENDA Enzyme Link: BRENDA 3.1.3.86
KEGG Enzyme Link: KEGG3.1.3.86
BioCyc Enzyme Link: BioCyc 3.1.3.86
ExPASy Enzyme Link: ExPASy3.1.3.86
EC2PDB Enzyme Link: EC2PDB 3.1.3.86
ExplorEnz Enzyme Link: ExplorEnz 3.1.3.86
PRIAM enzyme-specific profiles Link: PRIAM 3.1.3.86
IntEnz Enzyme Link: IntEnz 3.1.3.86
MEDLINE Enzyme Link: MEDLINE 3.1.3.86
MSA:

3.1.3.86;

Phylogenetic Tree:

3.1.3.86;

Uniprot:
M-CSA:
RHEA:25528 a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.Drayer AL, Pesesse X, De Smedt F, Woscholski R, Parker P, Erneux C1996 Aug 58769125
The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity.Pesesse X, Moreau C, Drayer AL, Woscholski R, Parker P, Erneux C1998 Oct 239824312
p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.Lioubin MN, Algate PA, Tsai S, Carlberg K, Aebersold A, Rohrschneider LR1996 May 18654924
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G1996 Feb 208643691
Inositol polyphosphate phosphatidylinositol 5-phosphatase9 (At5ptase9) controls plant salt tolerance by regulating endocytosis.Golani Y, Kaye Y, Gilhar O, Ercetin M, Gillaspy G, Levine A2013 Nov23658066
Inositol polyphosphate 5-phosphatase7 regulates the production of reactive oxygen species and salt tolerance in Arabidopsis.Kaye Y, Golani Y, Singer Y, Leshem Y, Cohen G, Ercetin M, Gillaspy G, Levine A2011 Sep21677096
SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain.Hasegawa J, Tokuda E, Tenno T, Tsujita K, Sawai H, Hiroaki H, Takenawa T, Itoh T2011 May 3021624956
SHIP-2 and PTEN are expressed and active in vascular smooth muscle cell nuclei, but only SHIP-2 is associated with nuclear speckles.Déléris P, Bacqueville D, Gayral S, Carrez L, Salles JP, Perret B, Breton-Douillon M2003 Oct 312847108
The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase.Kisseleva MV, Wilson MP, Majerus PW2000 Jun 3010764818
A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells.Wisniewski D, Strife A, Swendeman S, Erdjument-Bromage H, Geromanos S, Kavanaugh WM, Tempst P, Clarkson B1999 Apr 1510194451