EC number:3.1.4.11
| ID: | 3.1.4.11 |
|---|---|
| Description: | Phosphoinositide phospholipase C. |
| Alternative Name: |
Triphosphoinositide phosphodiesterase. PI-PLC. Phosphoinositidase C. Phosphatidylinositol phospholipase C. Monophosphatidylinositol phosphodiesterase. 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase. inositoltrisphosphohydrolase. 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate |
| Cath: | 1.10.238.10; 1.20.1230.10; 3.20.20.190; 3.30.505.10; 2.30.29.240; 2.30.29.30; 2.30.30.40; 2.60.40.150; 3.10.20.90; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.4.11 |
| BRENDA Enzyme Link: | BRENDA 3.1.4.11 |
| KEGG Enzyme Link: | KEGG3.1.4.11 |
| BioCyc Enzyme Link: | BioCyc 3.1.4.11 |
| ExPASy Enzyme Link: | ExPASy3.1.4.11 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.4.11 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.4.11 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.4.11 |
| IntEnz Enzyme Link: | IntEnz 3.1.4.11 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.4.11 |
| RHEA:33179 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A novel phospholipase C delta4 (PLCdelta4) splice variant as a negative regulator of PLC. | Nagano K, Fukami K, Minagawa T, Watanabe Y, Ozaki C, Takenawa T | 1999 Jan 29 | 9915823 |
| Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs. | Tall E, Dormán G, Garcia P, Runnels L, Shah S, Chen J, Profit A, Gu QM, Chaudhary A, Prestwich GD, Rebecchi MJ | 1997 Jun 10 | 9188725 |
| A new phospholipase C delta 4 is induced at S-phase of the cell cycle and appears in the nucleus. | Liu N, Fukami K, Yu H, Takenawa T | 1996 Jan 5 | 8550586 |
| Cloning, sequencing, purification, and Gq-dependent activation of phospholipase C-beta 3. | Jhon DY, Lee HH, Park D, Lee CW, Lee KH, Yoo OJ, Rhee SG | 1993 Mar 25 | 8454637 |
| Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiae. | Flick JS, Thorner J | 1993 Sep | 8395015 |
| Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis. | Cheng HF, Jiang MJ, Chen CL, Liu SM, Wong LP, Lomasney JW, King K | 1995 Mar 10 | 7890667 |
| src-homology 2 (SH2) domain ligation as an allosteric regulator: modulation of phosphoinositide-specific phospholipase C gamma 1 structure and activity. | Koblan KS, Schaber MD, Edwards G, Gibbs JB, Pompliano DL | 1995 Feb 1 | 7531435 |
| A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency. | Zhou Q, Lee GS, Brady J, Datta S, Katan M, Sheikh A, Martins MS, Bunney TD, Santich BH, Moir S, Kuhns DB, Long Priel DA, Ombrello A, Stone D, Ombrello MJ, Khan J, Milner JD, Kastner DL, Aksentijevich I | 2012 Oct 5 | 23000145 |
| Phospholipase Cdelta3 regulates RhoA/Rho kinase signaling and neurite outgrowth. | Kouchi Z, Igarashi T, Shibayama N, Inanobe S, Sakurai K, Yamaguchi H, Fukuda T, Yanagi S, Nakamura Y, Fukami K | 2011 Mar 11 | 21187285 |
| Activation of human phospholipase C-eta2 by Gbetagamma. | Zhou Y, Sondek J, Harden TK | 2008 Apr 15 | 18361507 |
| A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme. | Nakahara M, Shimozawa M, Nakamura Y, Irino Y, Morita M, Kudo Y, Fukami K | 2005 Aug 12 | 15899900 |
| Regulation of phospholipase C-delta1 through direct interactions with the small GTPase Ral and calmodulin. | Sidhu RS, Clough RR, Bhullar RP | 2005 Jun 10 | 15817490 |
| Phospholipase Cbeta2 binds to and inhibits phospholipase Cdelta1. | Guo Y, Rebecchi M, Scarlata S | 2005 Jan 14 | 15509571 |
| Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells. | Leung DW, Tompkins C, Brewer J, Ball A, Coon M, Morris V, Waggoner D, Singer JW | 2004 May 13 | 15140260 |
| Phospholipase C-delta3 binds with high specificity to phosphatidylinositol 4,5-bisphosphate and phosphatidic acid in bilayer membranes. | Pawelczyk T, Matecki A | 1999 Jun | 10336610 |