EC number:3.1.4.12
| ID: | 3.1.4.12 |
|---|---|
| Description: | Sphingomyelin phosphodiesterase. |
| Alternative Name: |
Neutral sphingomyelinase. Acid sphingomyelinase. |
| Cath: | 3.60.10.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.4.12 |
| BRENDA Enzyme Link: | BRENDA 3.1.4.12 |
| KEGG Enzyme Link: | KEGG3.1.4.12 |
| BioCyc Enzyme Link: | BioCyc 3.1.4.12 |
| ExPASy Enzyme Link: | ExPASy3.1.4.12 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.4.12 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.4.12 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.4.12 |
| IntEnz Enzyme Link: | IntEnz 3.1.4.12 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.4.12 |
| RHEA:34739 | H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine = H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine |
| RULE(radius=1) | [*:1]-[P;H0;+0:2](-[*:3])(=[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](-[*:3])(=[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
| RHEA:19253 | H2O + sphingomyelin = an N-acylsphing-4-enine + H(+) + phosphocholine |
| RULE(radius=1) | [*:1]-[P;H0;+0:2](-[*:3])(=[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](-[*:3])(=[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Neutral sphingomyelinase-3 mediates TNF-stimulated oxidant activity in skeletal muscle. | Moylan JS, Smith JD, Wolf Horrell EM, McLean JB, Deevska GM, Bonnell MR, Nikolova-Karakashian MN, Reid MB | 2014 | 25180167 |
| Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs. | Schuchman EH, Suchi M, Takahashi T, Sandhoff K, Desnick RJ | 1991 May 5 | 1840600 |
| Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. | Marchesini N, Osta W, Bielawski J, Luberto C, Obeid LM, Hannun YA | 2004 Jun 11 | 15051724 |
| Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases. | Miura Y, Gotoh E, Nara F, Nishijima M, Hanada K | 2004 Jan 16 | 14741383 |
| Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family. | Duan RD, Bergman T, Xu N, Wu J, Cheng Y, Duan J, Nelander S, Palmberg C, Nilsson A | 2003 Oct 3 | 12885774 |
| Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase. | Hofmann K, Tomiuk S, Wolff G, Stoffel W | 2000 May 23 | 10823942 |
| Biochemical and molecular analysis of phospholipase C and phospholipase D activity in mycobacteria. | Johansen KA, Gill RE, Vasil ML | 1996 Aug | 8757862 |