EC number:3.1.4.17
3D structure
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3JWQ;
2H42;
3SIE;
3JWR;
3B2R;
1UDU;
6ACB;
5ZZ2;
5JO3;
4OEX;
4OEW;
4MD6;
4IA0;
4I9Z;
4G2Y;
4G2W;
3TGG;
3TGE;
3SHZ;
3SHY;
3HDZ;
3HC8;
3BJC;
2H44;
2H40;
2CHM;
1XP0;
1XOZ;
1UHO;
1UDT;
1TBF;
1T9R;
1RKP;
1SOJ;
1SO2;
6A3N;
4Y8C;
4Y87;
4Y86;
4GH6;
4G2L;
4G2J;
4E90;
3QI4;
3QI3;
3N3Z;
3K3H;
3K3E;
3JSW;
3JSI;
3DYS;
3DYQ;
3DYN;
3DY8;
2YY2;
2HD1;
5B25;
5W6E;
5UP0;
5UOY;
4NPW;
4NPV;
1TAZ;
3LY2;
5OHJ;
4X0F;
4WZI;
3WD9;
3W5E;
3KKT;
3HMV;
3G45;
1Y2J;
1Y2H;
1XOT;
1XN0;
1XMY;
1XMU;
1XM6;
1XM4;
1XLZ;
1XLX;
1TB5;
1ROR;
1RO9;
1RO6;
1F0J;
5LAQ;
5K6J;
4NW7;
4MYQ;
4KP6;
3O57;
3O56;
3O0J;
3GWT;
3FRG;
3D3P;
2QYL;
1XOS;
1MKD;
5K1I;
6NJJ;
6NJH;
6FW3;
6FTW;
6FTA;
6FT0;
6FET;
6FE7;
6FDI;
6BOJ;
5TKB;
5LBO;
4WCU;
4W1O;
4OGB;
3V9B;
3SL8;
3SL6;
3SL4;
3SL3;
3IAD;
3G58;
3G4L;
3G4K;
3G4I;
3G4G;
2FM5;
2FM0;
1ZKN;
1Q9M;
1PTW;
1OYN;
6NJI;
6FEB;
6FDC;
6F8X;
6F8W;
6F8V;
6F8U;
6F8T;
6F8R;
6F6U;
5WQA;
5WH6;
5WH5;
5K32;
2QYN;
2PW3;
1Y2K;
1Y2E;
1Y2D;
1Y2C;
1Y2B;
1XOR;
1XOQ;
1XON;
1TBB;
1TB7;
3K4S;
3IAK;
6MZB;
6MSC;
6MSA;
6IJI;
6IJH;
6CYD;
6CYC;
6CYB;
6C7J;
6C7I;
6C7G;
6C7F;
6C7E;
6C7D;
6BLF;
6B98;
6B97;
6B96;
5ZNL;
5XUJ;
5XUI;
5XKM;
5VP1;
5VP0;
5UWF;
5U7L;
5U7K;
5U7J;
5U7I;
5U7D;
5U00;
5TZZ;
5TZX;
5TZW;
5TZH;
5TZC;
5TZA;
5TZ3;
5K9R;
5I2R;
5EDI;
5EDH;
5EDG;
5EDE;
5DH5;
5DH4;
5C2H;
5C2E;
5C2A;
5C29;
5C28;
5C1W;
5B4L;
5B4K;
5AXQ;
5AXP;
4ZO5;
4YS7;
4YQH;
4Y2B;
4XY2;
4WN1;
4TPP;
4TPM;
4QGE;
4PM0;
4PHW;
4P1R;
4P0N;
4OJX;
4OJV;
4MVH;
4MUW;
4MSN;
4MSH;
4MSE;
4MSC;
4MSA;
4MS0;
4MRZ;
4MRW;
4LM4;
4LM3;
4LM2;
4LM1;
4LM0;
4LLX;
4LLP;
4LLK;
4LLJ;
4LKQ;
4JIB;
4HTZ;
4HTX;
4HF4;
4HEU;
4FCD;
4FCB;
4DFF;
4DDL;
4D09;
4D08;
4C1I;
4BBX;
4AJM;
4AJG;
4AJF;
4AJD;
4AEL;
3WYM;
3WYL;
3WYK;
3WS9;
3WS8;
3WI2;
3UUO;
3UI7;
3TVX;
3SNL;
3SNI;
3SN7;
3SL5;
3QPP;
3QPO;
3QPN;
3LXG;
3JBQ;
3JAB;
3ITU;
3ITM;
3IBJ;
3I8V;
3HR1;
3HQZ;
3HQY;
3HQW;
3G3N;
3ECN;
3ECM;
3DYL;
2Y0J;
2WEY;
2QYM;
2QYK;
2OVY;
2OVV;
2OUY;
2OUV;
2OUU;
2OUS;
2OUR;
2OUQ;
2OUP;
2OUN;
2O8H;
1ZKL;
1Z1L;
1XOM;
1T9S;
|
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References
External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.4.17 |
| BRENDA Enzyme Link: | BRENDA 3.1.4.17 |
| KEGG Enzyme Link: | KEGG3.1.4.17 |
| BioCyc Enzyme Link: | BioCyc 3.1.4.17 |
| ExPASy Enzyme Link: | ExPASy3.1.4.17 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.4.17 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.4.17 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.4.17 |
| IntEnz Enzyme Link: | IntEnz 3.1.4.17 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.4.17 |
| RHEA:14653 | a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](-[*:4])(=[*:5])-[*:6].[OH2;+0:7]>>([*:1]-[OH;+0:2].[*:4]-[P;H0;+0:3](=[*:5])(-[*:6])-[OH;+0:7]) |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cyclic nucleotide phosphodiesterase of Chlamydomonas reinhardtii. | Fischer U, Amrhein N | 1974 Apr 25 | 4365506 |
| X-ray crystal structure of phosphodiesterase 2 in complex with a highly selective, nanomolar inhibitor reveals a binding-induced pocket important for selectivity. | Zhu J, Yang Q, Dai D, Huang Q | 2013 Aug 14 | 23899287 |
| Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct. | Pandit J, Forman MD, Fennell KF, Dillman KS, Menniti FS | 2009 Oct 27 | 19828435 |
| A mycobacterial cyclic AMP phosphodiesterase that moonlights as a modifier of cell wall permeability. | Podobnik M, Tyagi R, Matange N, Dermol U, Gupta AK, Mattoo R, Seshadri K, Visweswariah SS | 2009 Nov 20 | 19801656 |
| The Rv0805 gene from Mycobacterium tuberculosis encodes a 3',5'-cyclic nucleotide phosphodiesterase: biochemical and mutational analysis. | Shenoy AR, Sreenath N, Podobnik M, Kovacevic M, Visweswariah SS | 2005 Dec 6 | 16313172 |
| Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity. | Scapin G, Patel SB, Chung C, Varnerin JP, Edmondson SD, Mastracchio A, Parmee ER, Singh SB, Becker JW, Van der Ploeg LH, Tota MR | 2004 May 25 | 15147193 |