Enzyme

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EC Tree
     3. Hydrolases
        3.1 Acting on ester bonds
            3.1.4 Phosphoric-diester hydrolases
ID:3.1.4.2
Description:Glycerophosphocholine phosphodiesterase.
Cath: 2.60.40.10;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 3.1.4.2
BRENDA Enzyme Link: BRENDA 3.1.4.2
KEGG Enzyme Link: KEGG3.1.4.2
BioCyc Enzyme Link: BioCyc 3.1.4.2
ExPASy Enzyme Link: ExPASy3.1.4.2
EC2PDB Enzyme Link: EC2PDB 3.1.4.2
ExplorEnz Enzyme Link: ExplorEnz 3.1.4.2
PRIAM enzyme-specific profiles Link: PRIAM 3.1.4.2
IntEnz Enzyme Link: IntEnz 3.1.4.2
MEDLINE Enzyme Link: MEDLINE 3.1.4.2
MSA:

3.1.4.2;

Phylogenetic Tree:

3.1.4.2;

Uniprot:
M-CSA:
RHEA:16061 H2O + sn-glycerol 3-phosphocholine = choline + H(+) + sn-glycerol 3-phosphate
RULE(radius=1) [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
A novel glycerophosphodiester phosphodiesterase, GDE5, controls skeletal muscle development via a non-enzymatic mechanism.Okazaki Y, Ohshima N, Yoshizawa I, Kamei Y, Mariggiò S, Okamoto K, Maeda M, Nogusa Y, Fujioka Y, Izumi T, Ogawa Y, Shiro Y, Wada M, Kato N, Corda D, Yanaka N2010 Sep 320576599
GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC.Gallazzini M, Ferraris JD, Burg MB2008 Aug 518667693
Glycerophosphocholine-dependent growth requires Gde1p (YPL110c) and Git1p in Saccharomyces cerevisiae.Fisher E, Almaguer C, Holic R, Griac P, Patton-Vogt J2005 Oct 2816141200