EC number:3.1.4.3
| ID: | 3.1.4.3 |
|---|---|
| Description: | Phospholipase C. |
| Alternative Name: |
Lipophosphodiesterase I. Lecithinase C. Clostridium welchii alpha-toxin. Clostridium oedematiens beta- and gamma-toxins. |
| Prosite: | PDOC00357; |
| PDB: |
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| Cath: | 1.10.575.10; 3.60.10.10; 2.60.60.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.4.3 |
| BRENDA Enzyme Link: | BRENDA 3.1.4.3 |
| KEGG Enzyme Link: | KEGG3.1.4.3 |
| BioCyc Enzyme Link: | BioCyc 3.1.4.3 |
| ExPASy Enzyme Link: | ExPASy3.1.4.3 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.4.3 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.4.3 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.4.3 |
| IntEnz Enzyme Link: | IntEnz 3.1.4.3 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.4.3 |
| RHEA:10604 | a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structure of the key toxin in gas gangrene. | Naylor CE, Eaton JT, Howells A, Justin N, Moss DS, Titball RW, Basak AK | 1998 Aug | 9699639 |
| Biochemical and molecular analysis of phospholipase C and phospholipase D activity in mycobacteria. | Johansen KA, Gill RE, Vasil ML | 1996 Aug | 8757862 |
| High-resolution (1.5 A) crystal structure of phospholipase C from Bacillus cereus. | Hough E, Hansen LK, Birknes B, Jynge K, Hansen S, Hordvik A, Little C, Dodson E, Derewenda Z | 1989 Mar 23 | 2493587 |
| The plant non-specific phospholipase C gene family. Novel competitors in lipid signalling. | Pokotylo I, Pejchar P, Potocký M, Kocourková D, Krčková Z, Ruelland E, Kravets V, Martinec J | 2013 Jan | 23089468 |
| Crystal structure of the C. perfringens alpha-toxin with the active site closed by a flexible loop region. | Eaton JT, Naylor CE, Howells AM, Moss DS, Titball RW, Basak AK | 2002 May 31 | 12051905 |
| Characterisation of the calcium-binding C-terminal domain of Clostridium perfringens alpha-toxin. | Naylor CE, Jepson M, Crane DT, Titball RW, Miller J, Basak AK, Bolgiano B | 1999 Dec 3 | 10610794 |