EC number:3.1.4.39
| ID: | 3.1.4.39 |
|---|---|
| Description: | Alkylglycerophosphoethanolamine phosphodiesterase. |
| Alternative Name: |
Lysophospholipase D. |
| Cath: | 4.10.410.20; 3.40.570.10; 3.40.720.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.4.39 |
| BRENDA Enzyme Link: | BRENDA 3.1.4.39 |
| KEGG Enzyme Link: | KEGG3.1.4.39 |
| BioCyc Enzyme Link: | BioCyc 3.1.4.39 |
| ExPASy Enzyme Link: | ExPASy3.1.4.39 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.4.39 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.4.39 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.4.39 |
| IntEnz Enzyme Link: | IntEnz 3.1.4.39 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.4.39 |
| RHEA:36203 | 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+) |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A lysophospholipase D pathway in the metabolism of ether-linked lipids in brain microsomes. | Wykle RL, Schremmer JM | 1974 Mar 25 | 4855486 |
| RHEA:15965 | 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+) |
| RULE(radius=1) | [*:1]-[P;H0;+0:2](-[*:3])(=[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](-[*:3])(=[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Studies of lysophospholipase D of rat liver and other tissues. | Wykle RL, Kraemer WF, Schremmer JM | 1977 Nov | 597368 |
| A lysophospholipase D pathway in the metabolism of ether-linked lipids in brain microsomes. | Wykle RL, Schremmer JM | 1974 Mar 25 | 4855486 |
| Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe. | Kawaguchi M, Okabe T, Okudaira S, Nishimasu H, Ishitani R, Kojima H, Nureki O, Aoki J, Nagano T | 2013 Aug 16 | 23688339 |
| Structural basis of substrate discrimination and integrin binding by autotaxin. | Hausmann J, Kamtekar S, Christodoulou E, Day JE, Wu T, Fulkerson Z, Albers HM, van Meeteren LA, Houben AJ, van Zeijl L, Jansen S, Andries M, Hall T, Pegg LE, Benson TE, Kasiem M, Harlos K, Kooi CW, Smyth SS, Ovaa H, Bollen M, Morris AJ, Moolenaar WH, Perrakis A | 2011 Feb | 21240271 |
| Crystal structure of autotaxin and insight into GPCR activation by lipid mediators. | Nishimasu H, Okudaira S, Hama K, Mihara E, Dohmae N, Inoue A, Ishitani R, Takagi J, Aoki J, Nureki O | 2011 Feb | 21240269 |