EC number:3.1.4.4
| ID: | 3.1.4.4 |
|---|---|
| Description: | Phospholipase D. |
| Alternative Name: |
Lipophosphodiesterase II. Lecithinase D. Choline phosphatase. |
| Cath: | 3.20.20.190; 3.30.870.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.4.4 |
| BRENDA Enzyme Link: | BRENDA 3.1.4.4 |
| KEGG Enzyme Link: | KEGG3.1.4.4 |
| BioCyc Enzyme Link: | BioCyc 3.1.4.4 |
| ExPASy Enzyme Link: | ExPASy3.1.4.4 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.4.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.4.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.4.4 |
| IntEnz Enzyme Link: | IntEnz 3.1.4.4 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.4.4 |
| RHEA:38995 | a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphate + choline + H(+) |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural basis of substrate discrimination and integrin binding by autotaxin. | Hausmann J, Kamtekar S, Christodoulou E, Day JE, Wu T, Fulkerson Z, Albers HM, van Meeteren LA, Houben AJ, van Zeijl L, Jansen S, Andries M, Hall T, Pegg LE, Benson TE, Kasiem M, Harlos K, Kooi CW, Smyth SS, Ovaa H, Bollen M, Morris AJ, Moolenaar WH, Perrakis A | 2011 Feb | 21240271 |
| Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. | Clair T, Aoki J, Koh E, Bandle RW, Nam SW, Ptaszynska MM, Mills GB, Schiffmann E, Liotta LA, Stracke ML | 2003 Sep 1 | 14500380 |
| Serum lysophosphatidic acid is produced through diverse phospholipase pathways. | Aoki J, Taira A, Takanezawa Y, Kishi Y, Hama K, Kishimoto T, Mizuno K, Saku K, Taguchi R, Arai H | 2002 Dec 13 | 12354767 |
| RHEA:36219 | 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+) |
| RULE(radius=1) | [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
| RHEA:14445 | a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+) |
| RULE(radius=1) | [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning, overexpression, and characterization of a bacterial Ca2+-dependent phospholipase D. | Yang H, Roberts MF | 2002 Dec | 12441393 |
| Phospholipase D. | Exton JH | 2000 Apr | 10818442 |