EC number:3.1.4.53
| ID: | 3.1.4.53 | ||
|---|---|---|---|
| Description: | 3',5'-cyclic-AMP phosphodiesterase. | ||
| Alternative Name: |
cAMP-specific phosphodiesterase. cAMP-specific PDE. | ||
| Prosite: | PDOC00116; | ||
| PDB: |
|
||
| Cath: | 1.10.1300.10; 3.30.750.180; 3.60.21.10; 3.60.21.40; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.4.53 |
| BRENDA Enzyme Link: | BRENDA 3.1.4.53 |
| KEGG Enzyme Link: | KEGG3.1.4.53 |
| BioCyc Enzyme Link: | BioCyc 3.1.4.53 |
| ExPASy Enzyme Link: | ExPASy3.1.4.53 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.4.53 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.4.53 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.4.53 |
| IntEnz Enzyme Link: | IntEnz 3.1.4.53 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.4.53 |
| RHEA:25277 | 3',5'-cyclic AMP + H2O = AMP + H(+) |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>([*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7]) |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A mycobacterial cyclic AMP phosphodiesterase that moonlights as a modifier of cell wall permeability. | Podobnik M, Tyagi R, Matange N, Dermol U, Gupta AK, Mattoo R, Seshadri K, Visweswariah SS | 2009 Nov 20 | 19801656 |
| The Rv0805 gene from Mycobacterium tuberculosis encodes a 3',5'-cyclic nucleotide phosphodiesterase: biochemical and mutational analysis. | Shenoy AR, Sreenath N, Podobnik M, Kovacevic M, Visweswariah SS | 2005 Dec 6 | 16313172 |
| Identification of the cpdA gene encoding cyclic 3',5'-adenosine monophosphate phosphodiesterase in Escherichia coli. | Imamura R, Yamanaka K, Ogura T, Hiraga S, Fujita N, Ishihama A, Niki H | 1996 Oct 11 | 8810311 |
| In vitro and in vivo characterization of the Pseudomonas aeruginosa cyclic AMP (cAMP) phosphodiesterase CpdA, required for cAMP homeostasis and virulence factor regulation. | Fuchs EL, Brutinel ED, Klem ER, Fehr AR, Yahr TL, Wolfgang MC | 2010 Jun | 20348254 |
| Characterization of the memory gene dunce of Drosophila melanogaster. | Qiu YH, Chen CN, Malone T, Richter L, Beckendorf SK, Davis RL | 1991 Dec 5 | 1660926 |
| Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans. | Gamanuma M, Yuasa K, Sasaki T, Sakurai N, Kotera J, Omori K | 2003 Jun | 12681444 |