EC number:3.1.4.54
| ID: | 3.1.4.54 |
|---|---|
| Description: | N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D. |
| Alternative Name: |
N-acyl phosphatidylethanolamine phospholipase D. Anandamide-generating phospholipase D. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.4.54 |
| BRENDA Enzyme Link: | BRENDA 3.1.4.54 |
| KEGG Enzyme Link: | KEGG3.1.4.54 |
| BioCyc Enzyme Link: | BioCyc 3.1.4.54 |
| ExPASy Enzyme Link: | ExPASy3.1.4.54 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.4.54 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.4.54 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.4.54 |
| IntEnz Enzyme Link: | IntEnz 3.1.4.54 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.4.54 |
| RHEA:33159 | H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-acylethanolamine |
| RULE(radius=1) | [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mammalian cells stably overexpressing N-acylphosphatidylethanolamine-hydrolysing phospholipase D exhibit significantly decreased levels of N-acylphosphatidylethanolamines. | Okamoto Y, Morishita J, Wang J, Schmid PC, Krebsbach RJ, Schmid HH, Ueda N | 2005 Jul 1 | 15760304 |
| Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-beta-lactamase family. | Wang J, Okamoto Y, Morishita J, Tsuboi K, Miyatake A, Ueda N | 2006 May 5 | 16527816 |
| Presence and potential signaling function of N-acylethanolamines and their phospholipid precursors in the yeast Saccharomyces cerevisiae. | Merkel O, Schmid PC, Paltauf F, Schmid HH | 2005 Jun 1 | 15878693 |
| Molecular characterization of a phospholipase D generating anandamide and its congeners. | Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N | 2004 Feb 13 | 14634025 |
| Bile Acid Recognition by NAPE-PLD. | Margheritis E, Castellani B, Magotti P, Peruzzi S, Romeo E, Natali F, Mostarda S, Gioiello A, Piomelli D, Garau G | 2016 Oct 21 | 27571266 |
| Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids. | Magotti P, Bauer I, Igarashi M, Babagoli M, Marotta R, Piomelli D, Garau G | 2015 Mar 3 | 25684574 |