EC number:3.1.4.59
| ID: | 3.1.4.59 |
|---|---|
| Description: | Cyclic-di-AMP phosphodiesterase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.4.59 |
| BRENDA Enzyme Link: | BRENDA 3.1.4.59 |
| KEGG Enzyme Link: | KEGG3.1.4.59 |
| BioCyc Enzyme Link: | BioCyc 3.1.4.59 |
| ExPASy Enzyme Link: | ExPASy3.1.4.59 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.4.59 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.4.59 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.4.59 |
| IntEnz Enzyme Link: | IntEnz 3.1.4.59 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.4.59 |
| RHEA:54420 | c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+) |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>([*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7]) |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence. | Huynh TN, Luo S, Pensinger D, Sauer JD, Tong L, Woodward JJ | 2015 Feb 17 | 25583510 |
| Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection. | Witte CE, Whiteley AT, Burke TP, Sauer JD, Portnoy DA, Woodward JJ | 2013 May 28 | 23716572 |
| YybT is a signaling protein that contains a cyclic dinucleotide phosphodiesterase domain and a GGDEF domain with ATPase activity. | Rao F, See RY, Zhang D, Toh DC, Ji Q, Liang ZX | 2010 Jan 1 | 19901023 |
| New Insights into the Cyclic Di-adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic Dinucleotide for Acid Stress Resistance in Staphylococcus aureus. | Bowman L, Zeden MS, Schuster CF, Kaever V, Gründling A | 2016 Dec 30 | 27834680 |
| Loss of function of the gdpP protein leads to joint β-lactam/glycopeptide tolerance in Staphylococcus aureus. | Griffiths JM, O'Neill AJ | 2012 Jan | 21986827 |
| c-di-AMP is a new second messenger in Staphylococcus aureus with a role in controlling cell size and envelope stress. | Corrigan RM, Abbott JC, Burhenne H, Kaever V, Gründling A | 2011 Sep | 21909268 |