EC number:3.11.1.1
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.11 Acting on carbon-phosphorus bonds |
| 3.11.1 Acting on carbon-phosphorus bonds (only sub-subclass identified to date) |
| ID: | 3.11.1.1 |
|---|---|
| Description: | Phosphonoacetaldehyde hydrolase. |
| Alternative Name: |
Phosphonoacetylaldehyde phosphonohydrolase. Phosphonatase. 2-phosphonoacetylaldehyde phosphonohydrolase. |
| Cath: | 1.10.150.240; 3.40.50.1000; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.11.1.1 |
| BRENDA Enzyme Link: | BRENDA 3.11.1.1 |
| KEGG Enzyme Link: | KEGG3.11.1.1 |
| BioCyc Enzyme Link: | BioCyc 3.11.1.1 |
| ExPASy Enzyme Link: | ExPASy3.11.1.1 |
| EC2PDB Enzyme Link: | EC2PDB 3.11.1.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.11.1.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.11.1.1 |
| IntEnz Enzyme Link: | IntEnz 3.11.1.1 |
| MEDLINE Enzyme Link: | MEDLINE 3.11.1.1 |
| RHEA:18905 | H2O + phosphonoacetaldehyde = acetaldehyde + H(+) + phosphate |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[CH3;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Insights into the mechanism of catalysis by the P-C bond-cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis. | Baker AS, Ciocci MJ, Metcalf WW, Kim J, Babbitt PC, Wanner BL, Martin BM, Dunaway-Mariano D | 1998 Jun 30 | 9649311 |
| Investigation of the Bacillus cereus phosphonoacetaldehyde hydrolase. Evidence for a Schiff base mechanism and sequence analysis of an active-site peptide containing the catalytic lysine residue. | Olsen DB, Hepburn TW, Moos M, Mariano PS, Dunaway-Mariano D | 1988 Mar 22 | 3132206 |
| Investigation of metal ion binding in phosphonoacetaldehyde hydrolase identifies sequence markers for metal-activated enzymes of the HAD enzyme superfamily. | Zhang G, Morais MC, Dai J, Zhang W, Dunaway-Mariano D, Allen KN | 2004 May 4 | 15109258 |
| Analysis of the substrate specificity loop of the HAD superfamily cap domain. | Lahiri SD, Zhang G, Dai J, Dunaway-Mariano D, Allen KN | 2004 Mar 16 | 15005616 |
| X-ray crystallographic and site-directed mutagenesis analysis of the mechanism of Schiff-base formation in phosphonoacetaldehyde hydrolase catalysis. | Morais MC, Zhang G, Zhang W, Olsen DB, Dunaway-Mariano D, Allen KN | 2004 Mar 5 | 14670958 |