EC number:3.2.1.45
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.2 Glycosylases |
| 3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds |
| ID: | 3.2.1.45 |
|---|---|
| Description: | Glucosylceramidase. |
| Alternative Name: |
D-glucosyl-N-acylsphingosine glucohydrolase. Beta-glucocerebrosidase. Acid beta-glucosidase. |
| Cath: | 3.20.20.80; 2.60.40.1180; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.2.1.45 |
| BRENDA Enzyme Link: | BRENDA 3.2.1.45 |
| KEGG Enzyme Link: | KEGG3.2.1.45 |
| BioCyc Enzyme Link: | BioCyc 3.2.1.45 |
| ExPASy Enzyme Link: | ExPASy3.2.1.45 |
| EC2PDB Enzyme Link: | EC2PDB 3.2.1.45 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.2.1.45 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.2.1.45 |
| IntEnz Enzyme Link: | IntEnz 3.2.1.45 |
| MEDLINE Enzyme Link: | MEDLINE 3.2.1.45 |
| RHEA:13269 | a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[*:5].[OH2;+0:6]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:6].[*:5]-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases. | Marques AR, Mirzaian M, Akiyama H, Wisse P, Ferraz MJ, Gaspar P, Ghauharali-van der Vlugt K, Meijer R, Giraldo P, Alfonso P, Irún P, Dahl M, Karlsson S, Pavlova EV, Cox TM, Scheij S, Verhoek M, Ottenhoff R, van Roomen CP, Pannu NS, van Eijk M, Dekker N, Boot RG, Overkleeft HS, Blommaart E, Hirabayashi Y, Aerts JM | 2016 Mar | 26724485 |
| Cholesterol glucosylation is catalyzed by transglucosylation reaction of β-glucosidase 1. | Akiyama H, Kobayashi S, Hirabayashi Y, Murakami-Murofushi K | 2013 Nov 29 | 24211208 |
| Characterization of human glucosylsphingosine glucosyl hydrolase and comparison with glucosylceramidase. | Vaccaro AM, Muscillo M, Suzuki K | 1985 Jan 15 | 3967661 |
| Mutation of beta-glucosidase 2 causes glycolipid storage disease and impaired male fertility. | Yildiz Y, Matern H, Thompson B, Allegood JC, Warren RL, Ramirez DM, Hammer RE, Hamra FK, Matern S, Russell DW | 2006 Nov | 17080196 |
| Use of fluorescent substrates for characterization of Gaucher disease mutations. | Ron I, Dagan A, Gatt S, Pasmanik-Chor M, Horowitz M | 2005 Jul-Aug | 15916907 |
| THE METABOLISM OF GLUCOCEREBROSIDES. I. PURIFICATION AND PROPERTIES OF A GLUCOCEREBROSIDE-CLEAVING ENZYME FROM SPLEEN TISSUE. | BRADY RO, KANFER J, SHAPIRO D | 1965 Jan | 14253443 |