EC number:3.2.1.46
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.2 Glycosylases |
| 3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds |
| ID: | 3.2.1.46 |
|---|---|
| Description: | Galactosylceramidase. |
| Alternative Name: |
Galcerase. Galactosylceramide beta-galactosidase. Galactocerebroside beta-galactosidase. Galactocerebrosidase. |
| Cath: | 3.20.20.70; 3.20.20.80; 2.60.120.560; 2.60.40.1180; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.2.1.46 |
| BRENDA Enzyme Link: | BRENDA 3.2.1.46 |
| KEGG Enzyme Link: | KEGG3.2.1.46 |
| BioCyc Enzyme Link: | BioCyc 3.2.1.46 |
| ExPASy Enzyme Link: | ExPASy3.2.1.46 |
| EC2PDB Enzyme Link: | EC2PDB 3.2.1.46 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.2.1.46 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.2.1.46 |
| IntEnz Enzyme Link: | IntEnz 3.2.1.46 |
| MEDLINE Enzyme Link: | MEDLINE 3.2.1.46 |
| RHEA:14297 | an N-acyl-beta-D-galactosyl-sphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[*:5].[OH2;+0:6]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:6].[*:5]-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of the rhesus monkey galactocerebrosidase (GALC) cDNA and gene and identification of the mutation causing globoid cell leukodystrophy (Krabbe disease) in this primate. | Luzi P, Rafi MA, Victoria T, Baskin GB, Wenger DA | 1997 Jun 1 | 9192853 |
| Molecular cloning and expression of cDNA for murine galactocerebrosidase and mutation analysis of the twitcher mouse, a model of Krabbe's disease. | Sakai N, Inui K, Tatsumi N, Fukushima H, Nishigaki T, Taniike M, Nishimoto J, Tsukamoto H, Yanagihara I, Ozono K, Okada S | 1996 Mar | 8769874 |
| Cloning of the canine GALC cDNA and identification of the mutation causing globoid cell leukodystrophy in West Highland White and Cairn terriers. | Victoria T, Rafi MA, Wenger DA | 1996 May 1 | 8661004 |
| Galactocerebrosidase from human urine: purification and partial characterization. | Chen YQ, Wenger DA | 1993 Sep 29 | 8399327 |
| Cloning and expression of cDNA encoding human galactocerebrosidase, the enzyme deficient in globoid cell leukodystrophy. | Chen YQ, Rafi MA, de Gala G, Wenger DA | 1993 Nov | 8281145 |