EC number:3.2.2.19
| ID: | 3.2.2.19 |
|---|---|
| Description: | [Protein ADP-ribosylarginine] hydrolase. |
| Alternative Name: |
N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase. ADP-ribosylarginine hydrolase. ADP-ribose-L-arginine cleaving enzyme. ADP-ribose-L-arginine cleavage enzyme. |
| Cath: | 1.10.4080.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.2.2.19 |
| BRENDA Enzyme Link: | BRENDA 3.2.2.19 |
| KEGG Enzyme Link: | KEGG3.2.2.19 |
| BioCyc Enzyme Link: | BioCyc 3.2.2.19 |
| ExPASy Enzyme Link: | ExPASy3.2.2.19 |
| EC2PDB Enzyme Link: | EC2PDB 3.2.2.19 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.2.2.19 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.2.2.19 |
| IntEnz Enzyme Link: | IntEnz 3.2.2.19 |
| MEDLINE Enzyme Link: | MEDLINE 3.2.2.19 |
| RHEA:20784 | H2O + N(omega)-(ADP-D-ribosyl)-L-arginine = ADP-D-ribose + L-arginine |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[CH;+0:3](-[*:4])-[*:5].[OH2;+0:6]>>[*:4]-[CH;+0:3](-[*:5])-[OH;+0:6].[*:1]-[NH2;+0:2] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase. | Ohno T, Tsuchiya M, Osago H, Hara N, Jidoi J, Shimoyama M | 1995 Oct 10 | 8678289 |
| Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase. | Takada T, Iida K, Moss J | 1993 Aug 25 | 8349667 |
| Reversibility of arginine-specific mono(ADP-ribosyl)ation: identification in erythrocytes of an ADP-ribose-L-arginine cleavage enzyme. | Moss J, Jacobson MK, Stanley SJ | 1985 Sep | 2994036 |
| Identification of critical, conserved vicinal aspartate residues in mammalian and bacterial ADP-ribosylarginine hydrolases. | Konczalik P, Moss J | 1999 Jun 11 | 10358013 |
| RHEA:14885 | H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] = ADP-D-ribose + L-arginyl-[protein] |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[CH;+0:3](-[*:4])-[*:5].[OH2;+0:6]>>[*:4]-[CH;+0:3](-[*:5])-[OH;+0:6].[*:1]-[NH2;+0:2] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase. | Ohno T, Tsuchiya M, Osago H, Hara N, Jidoi J, Shimoyama M | 1995 Oct 10 | 8678289 |
| Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase. | Takada T, Iida K, Moss J | 1993 Aug 25 | 8349667 |
| Reversibility of arginine-specific mono(ADP-ribosyl)ation: identification in erythrocytes of an ADP-ribose-L-arginine cleavage enzyme. | Moss J, Jacobson MK, Stanley SJ | 1985 Sep | 2994036 |
| Molecular and immunological characterization of ADP-ribosylarginine hydrolases. | Moss J, Stanley SJ, Nightingale MS, Murtagh JJ Jr, Monaco L, Mishima K, Chen HC, Williamson KC, Tsai SC | 1992 May 25 | 1375222 |
| Identification of critical, conserved vicinal aspartate residues in mammalian and bacterial ADP-ribosylarginine hydrolases. | Konczalik P, Moss J | 1999 Jun 11 | 10358013 |