EC number:3.2.2.5

Enzyme

Download
EC Tree
     3. Hydrolases
        3.2 Glycosylases
            3.2.2 Hydrolysing N-glycosyl compounds
ID:3.2.2.5
Description:NAD(+) glycohydrolase.
Alternative Name: Nicotinamide adenine dinucleotide nucleosidase.
Nicotinamide adenine dinucleotide glycohydrolase.
NADase.
NAD(+) nucleosidase.
NAD nucleosidase.
NAD glycohydrolase.
DPNase.
DPN hydrolase.
Diphosphopyridine nucleosidase.
Beta-NAD(+) glycohydrolase.
ADP-ribosyl cyclase.
Cath: 3.40.50.720; 3.90.176.10; 1.20.82.10;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.2.2.5
BRENDA Enzyme Link: BRENDA 3.2.2.5
KEGG Enzyme Link: KEGG3.2.2.5
BioCyc Enzyme Link: BioCyc 3.2.2.5
ExPASy Enzyme Link: ExPASy3.2.2.5
EC2PDB Enzyme Link: EC2PDB 3.2.2.5
ExplorEnz Enzyme Link: ExplorEnz 3.2.2.5
PRIAM enzyme-specific profiles Link: PRIAM 3.2.2.5
IntEnz Enzyme Link: IntEnz 3.2.2.5
MEDLINE Enzyme Link: MEDLINE 3.2.2.5

EC number:3.2.2.5

MSA:

3.2.2.5;
Phylogenetic Tree:

3.2.2.5;
Uniprot:
M-CSA:
RHEA:16301 H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[n+;H0:4](:[*:5]):[*:6].[OH2;+0:7]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:7].[*:5]:[n;H0;+0:4]:[*:6]
Reaction
Core-to-Core More
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38.Howard M, Grimaldi JC, Bazan JF, Lund FE, Santos-Argumedo L, Parkhouse RM, Walseth TF, Lee HC1993 Nov 128235624
Mouse T-cell antigen rt6.1 has thiol-dependent NAD glycohydrolase activity.Hara N, Terashima M, Shimoyama M, Tsuchiya M2000 Oct11011142