EC number:3.3.2.10
| ID: | 3.3.2.10 |
|---|---|
| Description: | Soluble epoxide hydrolase. |
| Alternative Name: |
Trans-stilbene oxide hydrolase. Epoxide hydratase. Epoxide hydrase. Cytosolic epoxide hydrolase. Aryl epoxide hydrase. Arene-oxide hydratase. |
| Cath: | 1.10.150.240; 3.10.450.50; 3.40.50.1000; 3.40.50.1820; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.3.2.10 |
| BRENDA Enzyme Link: | BRENDA 3.3.2.10 |
| KEGG Enzyme Link: | KEGG3.3.2.10 |
| BioCyc Enzyme Link: | BioCyc 3.3.2.10 |
| ExPASy Enzyme Link: | ExPASy3.3.2.10 |
| EC2PDB Enzyme Link: | EC2PDB 3.3.2.10 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.3.2.10 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.3.2.10 |
| IntEnz Enzyme Link: | IntEnz 3.3.2.10 |
| MEDLINE Enzyme Link: | MEDLINE 3.3.2.10 |
| RHEA:19037 | an epoxide + H2O = an ethanediol |
| RULE(radius=1) | [C;+0:2]1(-[*:3])-[*:4]-[O;H0;+0:5]-1.[OH2;+0:6]>>[C;+0:2](-[*:3])(-[OH;+0:6])-[*:4]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. | Newman JW, Morisseau C, Harris TR, Hammock BD | 2003 Feb 18 | 12574510 |
| The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase. | Cronin A, Mowbray S, Dürk H, Homburg S, Fleming I, Fisslthaler B, Oesch F, Arand M | 2003 Feb 18 | 12574508 |
| Structure of an atypical epoxide hydrolase from Mycobacterium tuberculosis gives insights into its function. | Johansson P, Unge T, Cronin A, Arand M, Bergfors T, Jones TA, Mowbray SL | 2005 Sep 2 | 16051262 |
| Epoxide hydrolases: their roles and interactions with lipid metabolism. | Newman JW, Morisseau C, Hammock BD | 2005 Jan | 15748653 |
| Epoxide hydrolases: biochemistry and molecular biology. | Fretland AJ, Omiecinski CJ | 2000 Dec 1 | 11154734 |
| EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. | Decker M, Adamska M, Cronin A, Di Giallonardo F, Burgener J, Marowsky A, Falck JR, Morisseau C, Hammock BD, Gruzdev A, Zeldin DC, Arand M | 2012 Oct | 22798687 |
| Identification of two epoxide hydrolases in Caenorhabditis elegans that metabolize mammalian lipid signaling molecules. | Harris TR, Aronov PA, Jones PD, Tanaka H, Arand M, Hammock BD | 2008 Apr 15 | 18267101 |
| Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles. | Morisseau C, Hammock BD | 2005 | 15822179 |
| Asp333, Asp495, and His523 form the catalytic triad of rat soluble epoxide hydrolase. | Arand M, Wagner H, Oesch F | 1996 Feb 23 | 8626766 |
| Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis. | Zeldin DC, Wei S, Falck JR, Hammock BD, Snapper JR, Capdevila JH | 1995 Jan 10 | 7840649 |
| Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds. | Oesch F | 1973 May | 4584115 |
| Leukotriene A4. Enzymatic conversion into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid by mouse liver cytosolic epoxide hydrolase. | Haeggström J, Meijer J, Rådmark O | 1986 May 15 | 3009453 |
| A leukotriene A4 hydrolase-related aminopeptidase from yeast undergoes induced fit upon inhibitor binding. | Helgstrand C, Hasan M, Uysal H, Haeggström JZ, Thunnissen MM | 2011 Feb 11 | 21146536 |
| Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. | Yu Z, Xu F, Huse LM, Morisseau C, Draper AJ, Newman JW, Parker C, Graham L, Engler MM, Hammock BD, Zeldin DC, Kroetz DL | 2000 Nov 24 | 11090543 |