EC number:3.3.2.11
| ID: | 3.3.2.11 |
|---|---|
| Description: | Cholesterol-5,6-oxide hydrolase. |
| Alternative Name: |
Cholesterol-epoxide hydrolase. ChEH. |
| Cath: | 3.10.450.50; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.3.2.11 |
| BRENDA Enzyme Link: | BRENDA 3.3.2.11 |
| KEGG Enzyme Link: | KEGG3.3.2.11 |
| BioCyc Enzyme Link: | BioCyc 3.3.2.11 |
| ExPASy Enzyme Link: | ExPASy3.3.2.11 |
| EC2PDB Enzyme Link: | EC2PDB 3.3.2.11 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.3.2.11 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.3.2.11 |
| IntEnz Enzyme Link: | IntEnz 3.3.2.11 |
| MEDLINE Enzyme Link: | MEDLINE 3.3.2.11 |
| RHEA:15113 | 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol |
| RULE(radius=1) | [C;+0:2]1(-[*:3])-[*:4]-[O;H0;+0:5]-1.[OH2;+0:6]>>[C;+0:2](-[*:3])(-[OH;+0:6])-[*:4]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Existence of multiple forms of microsomal epoxide hydrolases with radically different substrate specificities. | Oesch F, Timms CW, Walker CH, Guenthner TM, Sparrow A, Watabe T, Wolf CR | 1984 Jan | 6690087 |
| Distinct rat hepatic microsomal epoxide hydrolases catalyze the hydration of cholesterol 5,6 alpha-oxide and certain xenobiotic alkene and arene oxides. | Levin W, Michaud DP, Thomas PE, Jerina DM | 1983 Feb 1 | 6401984 |
| 7-Dehydrocholesterol 5,6 beta-oxide as a mechanism-based inhibitor of microsomal cholesterol oxide hydrolase. | Nashed NT, Michaud DP, Levin W, Jerina DM | 1986 Feb 25 | 3949731 |
| Catalytic properties and inhibition of hepatic cholesterol-epoxide hydrolase. | Sevanian A, McLeod LL | 1986 Jan 5 | 3941086 |
| Structure of an atypical epoxide hydrolase from Mycobacterium tuberculosis gives insights into its function. | Johansson P, Unge T, Cronin A, Arand M, Bergfors T, Jones TA, Mowbray SL | 2005 Sep 2 | 16051262 |
| Epoxide hydrolases: their roles and interactions with lipid metabolism. | Newman JW, Morisseau C, Hammock BD | 2005 Jan | 15748653 |
| Epoxide hydrolases: biochemistry and molecular biology. | Fretland AJ, Omiecinski CJ | 2000 Dec 1 | 11154734 |
| RHEA:11964 | 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol |
| RULE(radius=1) | [C;+0:2]1(-[*:3])-[*:4]-[O;H0;+0:5]-1.[OH2;+0:6]>>[C;+0:2](-[*:3])(-[OH;+0:6])-[*:4]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Existence of multiple forms of microsomal epoxide hydrolases with radically different substrate specificities. | Oesch F, Timms CW, Walker CH, Guenthner TM, Sparrow A, Watabe T, Wolf CR | 1984 Jan | 6690087 |
| Distinct rat hepatic microsomal epoxide hydrolases catalyze the hydration of cholesterol 5,6 alpha-oxide and certain xenobiotic alkene and arene oxides. | Levin W, Michaud DP, Thomas PE, Jerina DM | 1983 Feb 1 | 6401984 |
| 7-Dehydrocholesterol 5,6 beta-oxide as a mechanism-based inhibitor of microsomal cholesterol oxide hydrolase. | Nashed NT, Michaud DP, Levin W, Jerina DM | 1986 Feb 25 | 3949731 |
| Catalytic properties and inhibition of hepatic cholesterol-epoxide hydrolase. | Sevanian A, McLeod LL | 1986 Jan 5 | 3941086 |
| Structure of an atypical epoxide hydrolase from Mycobacterium tuberculosis gives insights into its function. | Johansson P, Unge T, Cronin A, Arand M, Bergfors T, Jones TA, Mowbray SL | 2005 Sep 2 | 16051262 |
| Epoxide hydrolases: their roles and interactions with lipid metabolism. | Newman JW, Morisseau C, Hammock BD | 2005 Jan | 15748653 |
| Epoxide hydrolases: biochemistry and molecular biology. | Fretland AJ, Omiecinski CJ | 2000 Dec 1 | 11154734 |