EC number:3.3.2.13
| ID: | 3.3.2.13 |
|---|---|
| Description: | Chorismatase. |
| Alternative Name: |
Chorismate/3,4-dihydroxycyclohexa-1,5-dienoate synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.3.2.13 |
| BRENDA Enzyme Link: | BRENDA 3.3.2.13 |
| KEGG Enzyme Link: | KEGG3.3.2.13 |
| BioCyc Enzyme Link: | BioCyc 3.3.2.13 |
| ExPASy Enzyme Link: | ExPASy3.3.2.13 |
| EC2PDB Enzyme Link: | EC2PDB 3.3.2.13 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.3.2.13 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.3.2.13 |
| IntEnz Enzyme Link: | IntEnz 3.3.2.13 |
| MEDLINE Enzyme Link: | MEDLINE 3.3.2.13 |
| RHEA:38319 | chorismate + H2O = (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[CH2;+0:3])-[O;H0;+0:4]-[*:5].[OH2;+0:6]>>[*:1]-[C;H0;+0:2](-[CH3;+0:3])=[O;H0;+0:6].[*:5]-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mechanistic implications for the chorismatase FkbO based on the crystal structure. | Juneja P, Hubrich F, Diederichs K, Welte W, Andexer JN | 2014 Jan 9 | 24036425 |
| Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate. | Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B | 2011 Mar 22 | 21383123 |