EC number:3.3.2.6

Enzyme

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EC Tree
     3. Hydrolases
        3.3 Acting on ether bonds
            3.3.2 Ether hydrolases
ID:3.3.2.6
Description:Leukotriene-A(4) hydrolase.
Alternative Name: LTA-4 hydrolase.
Leukotriene-A4 hydrolase.
Leukotriene A(4) hydrolase.
Prosite: PDOC00129;
PDB:
PDBScop
1HOV 8091368; 8091369;
3FIE 8079906; 8079907; 8079906; 8079907;
4GER 8069744; 8069745; 8069744; 8069745;
4F5C 8049254; 8053549; 8049254; 8053549; 8047039; 8054066; 8054067; 8054068; 8054069; 8054070; 8054071; 8054072; 8047039; 8054066; 8054067; 8054068; 8054069; 8054070; 8054071; 8054072;
3KBH 8049253; 8053550; 8024726; 8037105; 8049253; 8053550; 8024726; 8037105; 8049253; 8053550; 8024726; 8037105; 8049253; 8053550; 8024726; 8037105;
 » show all
Cath: 1.10.150.240; 1.10.1740.60; 1.10.390.10; 3.10.450.50; 3.40.630.10; 1.25.40.320; 3.40.50.1000; 3.40.50.1820; 2.60.40.1730;

3D structure

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PDB

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1HOV; 3FIE; 4GER; 4F5C; 3KBH; 5LHD; 6ATK; 4FYT; 4FYS; 4FYR; 4FYQ; 4KXD; 4KXC; 4KXB; 4KXA; 4KX9; 4KX8; 4KX7; 5MJ6; 5C97; 4Z7I; 4PJ6; 4P8Q; 5K1V; 5J6S; 5CU5; 5AB2; 5AB0; 4JBS; 4E36; 3SE6; 3Q7J; 1Z1W; 5LDS; 5LG6; 6BV4; 6BV3; 6BV2; 6BV1; 6BV0; 4OU3; 4NZ8; 4HOM; 4FKK; 4FKH; 4FKE; 3QNF; 3MDJ; 6Q4R; 2YD0; 4ZJX; 4ELC; 4EL4; 4EJ5; 3DS9; 3DDB; 3DDA; 3C8B; 3C8A; 3C89; 3C88; 3BWI; 6H5W; 6F9U; 6F9T; 4CA5; 4C2R; 4C2Q; 4C2P; 4C2O; 4C2N; 4BZR; 4APJ; 4APH; 3L3N; 3BKL; 3BKK; 2YDM; 2XY9; 2OC2; 2IUX; 2IUL; 1UZF; 1UZE; 1O8A; 1O86; 2J0T; 3V96; 1UEA; 6N9D; 1OO9; 3SSB; 8TLN; 8TLI; 7TLN; 7TLI; 6TMN; 6TLI; 6IG7; 6FJ2; 6D5U; 6D5T; 6D5S; 6D5R; 6D5Q; 6D5P; 6D5O; 6D5N; 5UUE; 5UUD; 5UUC; 5UUB; 5UUA; 5UU9; 5UU8; 5UU7; 5UN3; 5TMN; 5TLN; 5TLI; 5TAK; 5TAJ; 5TAI; 5TAE; 5TAD; 5TAC; 5T9Q; 5T9K; 5T9I; 5ONR; 5O8N; 5N3Y; 5N3V; 5N34; 5N31; 5N2Z; 5N2X; 5N2T; 5MNR; 5MA7; 5M9W; 5M69; 5M5F; 5LWD; 5LVD; 5LIF; 5L8P; 5L41; 5L3U; 5K7T; 5JXN; 5JVI; 5JT9; 5JSS; 5JS3; 5FXN; 5FSS; 5FSP; 5FSJ; 5DPF; 5DPE; 5A3Y; 4TNL; 4TMN; 4TLN; 4TLI; 4OW3; 4OI5; 4N66; 4N5P; 4N4E; 4MZN; 4MXJ; 4MWP; 4MTW; 4H57; 4D9W; 4D91; 3ZI6; 3TMN; 3TLI; 3T8H; 3T8G; 3T8F; 3T8D; 3T8C; 3T87; 3T74; 3T73; 3T2J; 3T2I; 3T2H; 3QH5; 3QH1; 3QGO; 3P7W; 3P7V; 3P7U; 3P7T; 3P7S; 3P7R; 3P7Q; 3P7P; 3NN7; 3N21; 3MSN; 3MSF; 3MSA; 3MS3; 3LS7; 3FXS; 3FXP; 3FVP; 3FV4; 3FOR; 3FGD; 3FCQ; 3FBO; 3FB0; 3F2P; 3F28; 3EIM; 3DO2; 3DO1; 3DO0; 3DNZ; 2WI0; 2WHZ; 2TMN; 2TLX; 2TLI; 2G4Z; 2A7G; 1ZDP; 1Z9G; 1Y3G; 1TMN; 1TLX; 1TLP; 1TLI; 1THL; 1QF2; 1QF1; 1QF0; 1PE8; 1PE7; 1PE5; 1OS0; 1LNF; 1LNE; 1LND; 1LNC; 1LNB; 1LNA; 1L3F; 1KTO; 1KS7; 1KRO; 1KR6; 1KL6; 1KKK; 1KJP; 1KJO; 1KEI; 1HYT; 1GXW; 1FJW; 1FJV; 1FJU; 1FJT; 1FJQ; 1FJO; 1FJ3; 1SMP; 3HDA; 3HBV; 3HBU; 1K7I; 1K7G; 1GO8; 3G42; 2I47; 1BKC; 3O64; 3LGP; 3LEA; 3LE9; 3L0V; 3L0T; 3KME; 3KMC; 3EWJ; 3EDZ; 3E8R; 2FV9; 2FV5; 2DDF; 2A8H; 1ZXC; 3CKI; 3B92; 2OI0; 1OS9; 1OS2; 6ELA; 4H49; 2WOA; 2WO9; 2WO8; 6ENM; 5L7F; 5I0L; 4H84; 4H30; 1UTZ; 1ROS; 1JIZ; 6EOX; 6EKN; 5N5K; 5N5J; 5LAB; 5L79; 5D3C; 5D2B; 5CZM; 5CXA; 4IJO; 4H76; 4GUY; 4GR8; 4GR3; 4GR0; 4GQL; 4EFS; 3TSK; 3TS4; 3RTT; 3RTS; 3NX7; 3N2V; 3N2U; 3LKA; 3LK8; 3LJG; 3LIR; 3LIL; 3LIK; 3F1A; 3F19; 3F18; 3F17; 3F16; 3F15; 3EHY; 3EHX; 3BA0; 2Z2D; 2OXZ; 2OXW; 2OXU; 2N8R; 2KRJ; 2K9C; 2K2G; 2HU6; 1Z3J; 1YCM; 1Y93; 1UTT; 1RMZ; 1R55; 1R54; 4ILW; 6ACJ; 3SCI; 3D0I; 6CS2; 6ACK; 6ACG; 3SCL; 3SCK; 3D0H; 1WNI; 5N0C; 5N0B; 5CUH; 4WZV; 4H3X; 4H2E; 1GKC; 5I12; 4XCT; 5TH6; 5TH9; 5UE4; 5UE3; 1L6J; 1RM8; 6FZX; 6F8B; 3DBK; 1U4G; 1EZM; 1KUK; 1KUI; 1KUG; 1KUF; 2E2D; 3FFZ; 1ZN3; 1ZL6; 1ZL5; 1ZKX; 1ZKW; 1T3A; 2W2D; 2NZ9; 3BTA; 2NYY; 1Q3A; 2O36; 1S4B; 3SHI; 1CGL; 1CGF; 966C; 4AYK; 3AYK; 2TCL; 2AYK; 1HFC; 1CGE; 1AYK; 1SU3; 5NIE; 5NI4; 6END; 6ENC; 5NID; 5NIA; 5NI6; 5NI2; 5N3W; 5FWQ; 5BPP; 5AEN; 4RVB; 4RSY; 4R7L; 4MS6; 4MKT; 4L2L; 4DPR; 3U9W; 3FUN; 3FUM; 3FUL; 3FUK; 3FUJ; 3FUI; 3FUH; 3FUF; 3FUE; 3FUD; 3FU6; 3FU5; 3FU3; 3FU0; 3FTZ; 3FTY; 3FTW; 3FTV; 3FTU; 3FTS; 3FHE; 3FH8; 3FH7; 3FH5; 3CHS; 3CHR; 3CHQ; 3CHP; 3CHO; 3B7U; 3B7R; 2VJ8; 2R59; 1SQM; 1HS6; 1H19; 1GW6; 1QIB; 3SCJ; 3D0G; 2AJF; 1R4L; 1R42; 2L0R; 5D1U; 5D1T; 5D1S; 4XM8; 4XM7; 4XM6; 4WF6; 4PKW; 4PKV; 4PKU; 4PKT; 4PKS; 4PKR; 4PKQ; 4DV8; 1YQY; 1PWV; 1PWQ; 1PWP; 1J7N; 1JKY; 2W15; 2W14; 2W13; 2W12; 1ND1; 1EB6; 1BUV; 1BQQ; 3MA2; 5H0U; 1MMP; 2Y6D; 2Y6C; 2DDY; 1MMR; 1MMQ; 1CXV; 6MAV; 1QIC; 1QIA; 1G4K; 4JA1; 4G9L; 4DPE; 2D1O; 1HY7; 1G49; 1G05; 1D8M; 1D8F; 1D7X; 1D5J; 1CQR; 1C3I; 1BQO; 1BIW; 3USN; 3OHO; 3OHL; 2USN; 2SRT; 2JT6; 2JT5; 2JNP; 1USN; 1UMT; 1UMS; 1SLN; 1HFS; 1CIZ; 1CAQ; 1BM6; 1B8Y; 1QUA; 1BUD; 1BSW; 1HTD; 1DTH; 1ATL; 4AIG; 3AIG; 2AIG; 1IAG; 6HT9; 1QJJ; 1QJI; 1IAE; 1IAD; 1IAC; 1IAB; 1IAA; 1AST; 3VI1; 1KAP; 1AKL; 4FXY; 2O3E; 1I1I; 5JMY; 6GID; 4CTH; 2YB9; 2QPJ; 1Y8J; 1R1J; 1R1I; 1R1H; 1DMT; 2XHL; 2ETF; 1F82; 3ZUQ; 2NP0; 1S0G; 1S0F; 1S0E; 1S0D; 1S0C; 1S0B; 1I1E; 1G9D; 1G9C; 1G9B; 1G9A; 1F31; 1EPW; 1LML; 1SRP; 1JIW; 2OZR; 5UWN; 3O2X; 3LJZ; 3KRY; 2PJT; 1ZTQ; 830C; 5UWM; 5UWL; 5UWK; 5BPA; 5BOY; 5BOT; 5B5P; 5B5O; 4L19; 4JPA; 4JP4; 4A7B; 456C; 3ZXH; 3WV3; 3WV2; 3WV1; 3KEK; 3KEJ; 3KEC; 3I7I; 3I7G; 3ELM; 2YIG; 2OW9; 2D1N; 1YOU; 1XUR; 1XUD; 1XUC; 3TVC; 1FM1; 1FLS; 1EUB; 3DPF; 3DNG; 2OY4; 2OY2; 1KBC; 5H8X; 4QKZ; 3TT4; 3DPE; 1ZVX; 1ZS0; 1ZP5; 1MNC; 1MMB; 1JJ9; 1JH1; 1JAQ; 1JAP; 1JAO; 1JAN; 1I76; 1I73; 1BZS; 1A86; 1A85; 1HV5; 1BQB; 1SLM; 1NPC; 1J38; 1J37; 1J36; 5A2R; 4CA8; 4CA7; 4ASR; 4ASQ; 4AA2; 4AA1; 3ZQZ; 2XHM; 2X97; 2X96; 2X94; 2X93; 2X92; 2X91; 2X90; 2X8Z; 2X8Y; 6QS1; 6MDW; 6H5X; 6GHX; 6G8B; 6FSM; 6F9V; 6F9R; 6EN6; 6EN5; 6EED; 6EE6; 6EE4; 6EE3; 6EAB; 6EAA; 6EA2; 6EA1; 6BUY; 6BTQ; 6BTP; 6BTO; 6BTN; 6BSM; 6BSL; 6BE6; 6BDZ; 5YQB; 5YQ2; 5YQ1; 5Y3I; 5Y1X; 5Y1W; 5Y1V; 5Y1T; 5Y1S; 5Y1R; 5Y1Q; 5Y1K; 5Y1H; 5Y19; 5XM7; 5WR6; 5WR5; 5WR4; 5WR3; 5WR2; 5VGX; 5VGV; 5V8U; 5V8R; 5V8P; 5V48; 5ONQ; 5ONP; 5O7E; 5MFT; 5MFS; 5MFR; 5KDX; 5KDW; 5KDV; 5JIG; 5DLH; 5D7W; 5BQM; 5AMC; 5AMB; 5AMA; 5AM9; 5AM8; 4ZX6; 4ZX5; 4ZX4; 4ZX3; 4ZW8; 4ZW7; 4ZW6; 4ZW5; 4ZW3; 4ZR5; 4XO5; 4XO4; 4XO3; 4XND; 4XNB; 4XNA; 4XN9; 4XN8; 4XN7; 4XN5; 4XN4; 4XN2; 4XN1; 4XMZ; 4XMX; 4XMW; 4XMV; 4XMU; 4XMT; 4XBH; 4X2U; 4WKI; 4WKE; 4WK7; 4UFB; 4UFA; 4R5X; 4R5V; 4R5T; 4Q4I; 4Q4E; 4Q1L; 4PUT; 4KUF; 4KTX; 4KS6; 4KA8; 4K90; 4K5P; 4K5O; 4K5N; 4K5M; 4K5L; 4J3B; 4J1L; 4IN9; 4I35; 4HEV; 4GWN; 4GWM; 4DD8; 4CA6; 4BZS; 4BXK; 4ARF; 4ARE; 4AR9; 4AR8; 4AR1; 3ZUS; 3VTG; 3T8V; 3QW8; 3QW7; 3QW6; 3QW5; 3QJX; 3QJ0; 3QIZ; 3QIY; 3QIX; 3Q44; 3Q43; 3Q2H; 3Q2G; 3PUU; 3NXQ; 3LUN; 3LUM; 3LJT; 3KED; 3K7N; 3K7L; 3K3Q; 3HYG; 3HY9; 3HY7; 3GBO; 3FTX; 3FLF; 3FII; 3EDI; 3EDH; 3EDG; 3EBI; 3EBH; 3EBG; 3DWB; 3DTK; 3DTI; 3DTE; 3DSL; 3DSE; 3DEB; 3BOO; 3BON; 3BOK; 3B8Z; 3B4R; 3B3B; 3B37; 3B34; 3B2X; 3B2P; 2ZXG; 2Y6I; 2Y50; 2Y3U; 2XYD; 2XS4; 2XS3; 2XQ0; 2XPZ; 2XPY; 2X95; 2V4B; 2RJQ; 2QN0; 2JSD; 2JIH; 2J83; 2ISH; 2ISG; 2ISE; 2IMC; 2IMB; 2IMA; 2ILP; 2HPT; 2HPO; 2FPQ; 2ERQ; 2ERP; 2ERO; 2E3X; 2DW2; 2DW1; 2DW0; 2DQM; 2DQ6; 2CKI; 2C6N; 2C6F; 2A97; 2A8A; 1ZXV; 1ZB7; 1Z7H; 1Z5H; 1YVG; 1Y79; 1SAT; 1FBL; 1B3D; 1AF0;

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.3.2.6
BRENDA Enzyme Link: BRENDA 3.3.2.6
KEGG Enzyme Link: KEGG3.3.2.6
BioCyc Enzyme Link: BioCyc 3.3.2.6
ExPASy Enzyme Link: ExPASy3.3.2.6
EC2PDB Enzyme Link: EC2PDB 3.3.2.6
ExplorEnz Enzyme Link: ExplorEnz 3.3.2.6
PRIAM enzyme-specific profiles Link: PRIAM 3.3.2.6
IntEnz Enzyme Link: IntEnz 3.3.2.6
MEDLINE Enzyme Link: MEDLINE 3.3.2.6

EC number:3.3.2.6

MSA:

3.3.2.6;
Phylogenetic Tree:

3.3.2.6;
Uniprot:
M-CSA:
RHEA:22324 H2O + leukotriene A4 = leukotriene B4
RULE(radius=1) [*:1]-[CH;+0:2]=[CH;+0:3]-[CH;+0:4]=[CH;+0:5]-[CH;+0:6]=[CH;+0:7]-[CH;+0:8]1-[*:9]-[O;H0;+0:10]-1.[OH2;+0:11]>>[*:1]-[CH;+0:2](-[OH;+0:11])-[CH;+0:3]=[CH;+0:4]-[CH;+0:5]=[CH;+0:6]-[CH;+0:7]=[CH;+0:8]-[*:9]-[OH;+0:10]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes.McGee J, Fitzpatrick F1985 Oct 152995393
The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype.Dalli J, Zhu M, Vlasenko NA, Deng B, Haeggström JZ, Petasis NA, Serhan CN2013 Jul23504711
Leukotriene A4 hydrolase in the human B-lymphocytic cell line Raji: indications of catalytically divergent forms of the enzyme.Odlander B, Claesson HE, Bergman T, Rådmark O, Jörnvall H, Haeggström JZ1991 May 151897988
Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates.Rudberg PC, Tholander F, Andberg M, Thunnissen MM, Haeggström JZ2004 Jun 2515078870