Enzyme

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     3. Hydrolases
        3.3 Acting on ether bonds
            3.3.2 Ether hydrolases
ID:3.3.2.7
Description:Hepoxilin-epoxide hydrolase.
Alternative Name: Hepoxylin hydrolase.
Hepoxilin epoxide hydrolase.
Hepoxilin A(3) hydrolase.
Cath: 3.10.450.50;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 3.3.2.7
BRENDA Enzyme Link: BRENDA 3.3.2.7
KEGG Enzyme Link: KEGG3.3.2.7
BioCyc Enzyme Link: BioCyc 3.3.2.7
ExPASy Enzyme Link: ExPASy3.3.2.7
EC2PDB Enzyme Link: EC2PDB 3.3.2.7
ExplorEnz Enzyme Link: ExplorEnz 3.3.2.7
PRIAM enzyme-specific profiles Link: PRIAM 3.3.2.7
IntEnz Enzyme Link: IntEnz 3.3.2.7
MEDLINE Enzyme Link: MEDLINE 3.3.2.7
MSA:

3.3.2.7;

Phylogenetic Tree:

3.3.2.7;

Uniprot:
M-CSA:
RHEA:16665 (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate
RULE(radius=1) [*:1]-[CH;+0:2]1-[*:3]-[O;H0;+0:4]-1.[OH2;+0:5]>>[*:1]-[CH;+0:2](-[OH;+0:5])-[*:3]-[OH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Formation and metabolism of hepoxilin A3 by the rat brain.Pace-Asciak CR1988 Feb 293348791
Purification of hepoxilin epoxide hydrolase from rat liver.Pace-Asciak CR, Lee WS1989 Jun 52722835
Epoxide hydrolases: their roles and interactions with lipid metabolism.Newman JW, Morisseau C, Hammock BD2005 Jan15748653
Epoxide hydrolases: biochemistry and molecular biology.Fretland AJ, Omiecinski CJ2000 Dec 111154734