EC number:3.4.17.13
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.4 Acting on peptide bonds (peptidases) |
| 3.4.17 Metallocarboxypeptidases |
| ID: | 3.4.17.13 |
|---|---|
| Description: | Muramoyltetrapeptide carboxypeptidase. |
| Alternative Name: |
Carboxypeptidase IIW. |
| Cath: | 3.40.80.10; 3.50.30.60; 3.90.1720.10; 3.40.50.10740; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.4.17.13 |
| BRENDA Enzyme Link: | BRENDA 3.4.17.13 |
| KEGG Enzyme Link: | KEGG3.4.17.13 |
| BioCyc Enzyme Link: | BioCyc 3.4.17.13 |
| ExPASy Enzyme Link: | ExPASy3.4.17.13 |
| EC2PDB Enzyme Link: | EC2PDB 3.4.17.13 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.4.17.13 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.4.17.13 |
| IntEnz Enzyme Link: | IntEnz 3.4.17.13 |
| MEDLINE Enzyme Link: | MEDLINE 3.4.17.13 |
EC number:3.4.17.13
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:48688 | H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine = D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[C;H0;+0:3](=[*:4])-[*:5].[OH2;+0:6]>>[*:1]-[NH2;+0:2].[*:4]=[C;H0;+0:3](-[*:5])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Penicillin-binding proteins and carboxypeptidase/transpeptidase activities in Proteus vulgaris P18 and its penicillin-induced stable L-forms. | Rousset A, Nguyen-Distèche M, Minck R, Ghuysen JM | 1982 Dec | 6754695 |
| LD-carboxypeptidase activity in Escherichia coli. II. Isolation, purification and characterization of the enzyme from E. coli K 12. | Metz R, Henning S, Hammes WP | 1986 Mar | 3521530 |
| Pseudomonas aeruginosa LD-carboxypeptidase, a serine peptidase with a Ser-His-Glu triad and a nucleophilic elbow. | Korza HJ, Bochtler M | 2005 Dec 9 | 16162494 |
| A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity. | Chang CI, Pili-Floury S, Hervé M, Parquet C, Chelliah Y, Lemaitre B, Mengin-Lecreulx D, Deisenhofer J | 2004 Sep | 15361936 |
| Purification and characterization of a carboxypeptidase-transpeptidase of Bacillus megaterium acting on the tetrapeptide moiety of the peptidoglycan. | DasGupta H, Fan DP | 1979 Jul 10 | 109439 |
| A defect in cell wall recycling triggers autolysis during the stationary growth phase of Escherichia coli. | Templin MF, Ursinus A, Höltje JV | 1999 Aug 2 | 10428950 |