EC number:3.4.19.14
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.4 Acting on peptide bonds (peptidases) |
| 3.4.19 Omega peptidases |
| ID: | 3.4.19.14 |
|---|---|
| Description: | Leukotriene-C(4) hydrolase. |
| Alternative Name: |
Gamma-glutamyl leukotrienase. |
| Cath: | 1.10.246.130; 3.60.20.40; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.4.19.14 |
| BRENDA Enzyme Link: | BRENDA 3.4.19.14 |
| KEGG Enzyme Link: | KEGG3.4.19.14 |
| BioCyc Enzyme Link: | BioCyc 3.4.19.14 |
| ExPASy Enzyme Link: | ExPASy3.4.19.14 |
| EC2PDB Enzyme Link: | EC2PDB 3.4.19.14 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.4.19.14 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.4.19.14 |
| IntEnz Enzyme Link: | IntEnz 3.4.19.14 |
| MEDLINE Enzyme Link: | MEDLINE 3.4.19.14 |
EC number:3.4.19.14
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:31563 | H2O + leukotriene C4 = L-glutamate + leukotriene D4 |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[*:3])-[NH;+0:4]-[*:5].[OH2;+0:6]>>[*:5]-[NH2;+0:4].[*:1]=[C;H0;+0:2](-[*:3])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice. | Carter BZ, Wiseman AL, Orkiszewski R, Ballard KD, Ou CN, Lieberman MW | 1997 May 9 | 9139674 |
| Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. | Wickham S, West MB, Cook PF, Hanigan MH | 2011 Jul 15 | 21447318 |
| Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo. | Han B, Luo G, Shi ZZ, Barrios R, Atwood D, Liu W, Habib GM, Sifers RN, Corry DB, Lieberman MW | 2002 Aug | 12163373 |
| Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response. | Shi ZZ, Han B, Habib GM, Matzuk MM, Lieberman MW | 2001 Aug | 11463821 |