EC number:3.5.1.103
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.1 In linear amides |
| ID: | 3.5.1.103 |
|---|---|
| Description: | deacetylase. |
| Alternative Name: |
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase. |
| Cath: | 3.40.50.10320; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.1.103 |
| BRENDA Enzyme Link: | BRENDA 3.5.1.103 |
| KEGG Enzyme Link: | KEGG3.5.1.103 |
| BioCyc Enzyme Link: | BioCyc 3.5.1.103 |
| ExPASy Enzyme Link: | ExPASy3.5.1.103 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.1.103 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.1.103 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.1.103 |
| IntEnz Enzyme Link: | IntEnz 3.5.1.103 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.1.103 |
EC number:3.5.1.103
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:26180 | 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[*:3])-[NH;+0:4]-[*:5].[OH2;+0:6]>>[*:5]-[NH2;+0:4].[*:1]=[C;H0;+0:2](-[*:3])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of Mycobacterium tuberculosis 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, MshB, a mycothiol biosynthetic enzyme. | Newton GL, Ko M, Ta P, Av-Gay Y, Fahey RC | 2006 Jun | 16630724 |
| Crystal structure of MshB from Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis. | McCarthy AA, Peterson NA, Knijff R, Baker EN | 2004 Jan 23 | 14698305 |
| The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold. | Maynes JT, Garen C, Cherney MM, Newton G, Arad D, Av-Gay Y, Fahey RC, James MN | 2003 Nov 21 | 12958317 |
| N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis. | Newton GL, Av-Gay Y, Fahey RC | 2000 Dec | 11092856 |