EC number:3.5.1.109

Enzyme

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     3. Hydrolases
        3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
            3.5.1 In linear amides
ID:3.5.1.109
Description:Sphingomyelin deacylase.
Alternative Name: Sphingomyelin glucosylceramide deacylase.
SMGCer deacylase.
SM glucosylceramide GCer deacylase.
SM deacylase.
Glucosylceramide sphingomyelin deacylase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.5.1.109
BRENDA Enzyme Link: BRENDA 3.5.1.109
KEGG Enzyme Link: KEGG3.5.1.109
BioCyc Enzyme Link: BioCyc 3.5.1.109
ExPASy Enzyme Link: ExPASy3.5.1.109
EC2PDB Enzyme Link: EC2PDB 3.5.1.109
ExplorEnz Enzyme Link: ExplorEnz 3.5.1.109
PRIAM enzyme-specific profiles Link: PRIAM 3.5.1.109
IntEnz Enzyme Link: IntEnz 3.5.1.109
MEDLINE Enzyme Link: MEDLINE 3.5.1.109

EC number:3.5.1.109

MSA:

3.5.1.109;
Phylogenetic Tree:

3.5.1.109;
Uniprot:
M-CSA:
RHEA:30915 a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[NH;+0:4]-[*:5].[OH2;+0:6]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:6].[*:5]-[NH2;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide.Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G2000 Sep 1510970788
High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis.Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G2000 Sep10951276
RHEA:30911 H2O + sphingomyelin = a carboxylate + sphing-4-enine-phosphocholine
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[NH;+0:4]-[*:5].[OH2;+0:6]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:6].[*:5]-[NH2;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide.Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G2000 Sep 1510970788
High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis.Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G2000 Sep10951276