EC number:3.5.1.124
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.1 In linear amides |
| ID: | 3.5.1.124 |
|---|---|
| Description: | Protein deglycase. |
| Alternative Name: |
Glyoxylase III. |
| Cath: | 3.40.50.880; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.1.124 |
| BRENDA Enzyme Link: | BRENDA 3.5.1.124 |
| KEGG Enzyme Link: | KEGG3.5.1.124 |
| BioCyc Enzyme Link: | BioCyc 3.5.1.124 |
| ExPASy Enzyme Link: | ExPASy3.5.1.124 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.1.124 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.1.124 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.1.124 |
| IntEnz Enzyme Link: | IntEnz 3.5.1.124 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.1.124 |
EC number:3.5.1.124
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:49556 | H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] = H(+) + L-cysteinyl-[protein] + lactate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[CH;+0:4](-[OH;+0:5])-[S;H0;+0:6]-[*:7].[OH2;+0:8]>>[*:1]-[CH;+0:2](-[OH;+0:3])-[C;H0;+0:4](=[O;H0;+0:5])-[OH;+0:8].[*:7]-[SH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Glyoxalase III from Escherichia coli: a single novel enzyme for the conversion of methylglyoxal into D-lactate without reduced glutathione. | Misra K, Banerjee AB, Ray S, Ray M | 1995 Feb 1 | 7848303 |
| The DJ-1 superfamily members YhbO and YajL from Escherichia coli repair proteins from glycation by methylglyoxal and glyoxal. | Abdallah J, Mihoub M, Gautier V, Richarme G | 2016 Feb 5 | 26774339 |
| The DJ-1 superfamily member Hsp31 repairs proteins from glycation by methylglyoxal and glyoxal. | Mihoub M, Abdallah J, Gontero B, Dairou J, Richarme G | 2015 Aug 7 | 26102038 |
| Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues. | Richarme G, Mihoub M, Dairou J, Bui LC, Leger T, Lamouri A | 2015 Jan 16 | 25416785 |
| Hsp31 of Escherichia coli K-12 is glyoxalase III. | Subedi KP, Choi D, Kim I, Min B, Park C | 2011 Aug | 21696459 |
| RHEA:49552 | H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] = H(+) + L-lysyl-[protein] + lactate |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[CH;+0:3](-[OH;+0:4])-[C;H0;+0:5](-[*:6])=[O;H0;+0:7].[OH2;+0:8]>>[*:6]-[CH;+0:5](-[OH;+0:7])-[C;H0;+0:3](=[O;H0;+0:4])-[OH;+0:8].[*:1]-[NH2;+0:2] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Glyoxalase III from Escherichia coli: a single novel enzyme for the conversion of methylglyoxal into D-lactate without reduced glutathione. | Misra K, Banerjee AB, Ray S, Ray M | 1995 Feb 1 | 7848303 |
| The DJ-1 superfamily members YhbO and YajL from Escherichia coli repair proteins from glycation by methylglyoxal and glyoxal. | Abdallah J, Mihoub M, Gautier V, Richarme G | 2016 Feb 5 | 26774339 |
| The DJ-1 superfamily member Hsp31 repairs proteins from glycation by methylglyoxal and glyoxal. | Mihoub M, Abdallah J, Gontero B, Dairou J, Richarme G | 2015 Aug 7 | 26102038 |
| Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues. | Richarme G, Mihoub M, Dairou J, Bui LC, Leger T, Lamouri A | 2015 Jan 16 | 25416785 |
| Hsp31 of Escherichia coli K-12 is glyoxalase III. | Subedi KP, Choi D, Kim I, Min B, Park C | 2011 Aug | 21696459 |
| RHEA:49548 | H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] = H(+) + L-arginyl-[protein] + lactate |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[CH;+0:3](-[OH;+0:4])-[C;H0;+0:5](-[*:6])=[O;H0;+0:7].[OH2;+0:8]>>[*:6]-[CH;+0:5](-[OH;+0:7])-[C;H0;+0:3](=[O;H0;+0:4])-[OH;+0:8].[*:1]-[NH2;+0:2] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Glyoxalase III from Escherichia coli: a single novel enzyme for the conversion of methylglyoxal into D-lactate without reduced glutathione. | Misra K, Banerjee AB, Ray S, Ray M | 1995 Feb 1 | 7848303 |
| The DJ-1 superfamily members YhbO and YajL from Escherichia coli repair proteins from glycation by methylglyoxal and glyoxal. | Abdallah J, Mihoub M, Gautier V, Richarme G | 2016 Feb 5 | 26774339 |
| The DJ-1 superfamily member Hsp31 repairs proteins from glycation by methylglyoxal and glyoxal. | Mihoub M, Abdallah J, Gontero B, Dairou J, Richarme G | 2015 Aug 7 | 26102038 |
| Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues. | Richarme G, Mihoub M, Dairou J, Bui LC, Leger T, Lamouri A | 2015 Jan 16 | 25416785 |
| Hsp31 of Escherichia coli K-12 is glyoxalase III. | Subedi KP, Choi D, Kim I, Min B, Park C | 2011 Aug | 21696459 |