EC number:3.5.1.19
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.1 In linear amides |
| ID: | 3.5.1.19 |
|---|---|
| Description: | Nicotinamidase. |
| Alternative Name: |
Nicotine deamidase. NAMase. |
| Cath: | 3.40.50.850; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.1.19 |
| BRENDA Enzyme Link: | BRENDA 3.5.1.19 |
| KEGG Enzyme Link: | KEGG3.5.1.19 |
| BioCyc Enzyme Link: | BioCyc 3.5.1.19 |
| ExPASy Enzyme Link: | ExPASy3.5.1.19 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.1.19 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.1.19 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.1.19 |
| IntEnz Enzyme Link: | IntEnz 3.5.1.19 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.1.19 |
| RHEA:14545 | H2O + nicotinamide = NH4(+) + nicotinate |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[*:3])-[NH2;+0:4].[OH2;+0:5]>>[*:1]=[C;H0;+0:2](-[*:3])-[OH;+0:5].[NH3;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification, cloning, and expression of the Escherichia coli pyrazinamidase and nicotinamidase gene, pncA. | Frothingham R, Meeker-O'Connell WA, Talbot EA, George JW, Kreuzer KN | 1996 Jun | 8726014 |
| Hyperproduction and purification of nicotinamide deamidase, a microconstitutive enzyme of Escherichia coli. | Pardee AB, Benz EJ Jr, St Peter DA, Krieger JN, Meuth M, Trieshmann HW Jr | 1971 Nov 25 | 4399474 |
| Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase. | Zhang H, Deng JY, Bi LJ, Zhou YF, Zhang ZP, Zhang CG, Zhang Y, Zhang XE | 2008 Feb | 18201201 |
| Nicotinamidase activity is important for germination. | Hunt L, Holdsworth MJ, Gray JE | 2007 Aug | 17587307 |
| Crystal structure of the yeast nicotinamidase Pnc1p. | Hu G, Taylor AB, McAlister-Henn L, Hart PJ | 2007 May 1 | 17382284 |
| Nicotinamidase participates in the salvage pathway of NAD biosynthesis in Arabidopsis. | Wang G, Pichersky E | 2007 Mar | 17335512 |
| NICOTINAMIDE DEAMIDASE FROM MAMMALIAN LIVER. | PETRACK B, GREENGARD P, CRASTON A, SHEPPY F | 1965 Apr | 14285515 |