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3. Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1 In linear amides

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UniProtKB Enzyme Link:	UniProtKB 3.5.1.23
BRENDA Enzyme Link:	BRENDA 3.5.1.23
KEGG Enzyme Link:	KEGG3.5.1.23
BioCyc Enzyme Link:	BioCyc 3.5.1.23
ExPASy Enzyme Link:	ExPASy3.5.1.23
EC2PDB Enzyme Link:	EC2PDB 3.5.1.23
ExplorEnz Enzyme Link:	ExplorEnz 3.5.1.23
PRIAM enzyme-specific profiles Link:	PRIAM 3.5.1.23
IntEnz Enzyme Link:	IntEnz 3.5.1.23
MEDLINE Enzyme Link:	MEDLINE 3.5.1.23

RHEA:20856	an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine
RULE(radius=1)	[:1]-[C;H0;+0:2](=[:3])-[NH;+0:4]-[:5].[OH2;+0:6]>>[:1]-[C;H0;+0:2](=[:3])-[OH;+0:6].[:5]-[NH2;+0:4]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes.	Xu R, Sun W, Jin J, Obeid LM, Mao C	2010 Jul	20207939
Expression, purification, and characterization of a recombinant neutral ceramidase from Mycobacterium tuberculosis.	Okino N, Ikeda R, Ito M	2010	20139604
Purification and characterization of human intestinal neutral ceramidase.	Ohlsson L, Palmberg C, Duan RD, Olsson M, Bergman T, Nilsson A	2007 Aug	17475390
Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides.	Mao C, Xu R, Szulc ZM, Bielawski J, Becker KP, Bielawska A, Galadari SH, Hu W, Obeid LM	2003 Aug 15	12783875