EC number:3.5.1.4
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.1 In linear amides |
3D structure
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Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.| PDB |
2E2L;
2E2K;
2DYV;
2DYU;
3KLC;
3KI8;
3IW3;
3IVZ;
4HGD;
4HG5;
4HG3;
4H5U;
2W1V;
1MT5;
6MRG;
4J5P;
4HBP;
4DO3;
3QKV;
3QK5;
3QJ9;
3QJ8;
3PR0;
3PPM;
3OJ8;
3LJ7;
3LJ6;
3K84;
3K83;
3K7F;
2WJ2;
2WJ1;
2WAP;
2VYA;
3AL0;
2GI3;
3IP4;
2G5H;
2DQN;
2DF4;
2F2A;
1F89;
1EMS;
3KFU;
2GGL;
2GGK;
1FO6;
1UF8;
1UF7;
1UF5;
1UF4;
1ERZ;
6FTQ;
6DII;
6DHV;
5XHQ;
5VRH;
5VRG;
5N6M;
5N6L;
5N6H;
5G3P;
5G3O;
4WJ3;
4N0I;
4N0H;
4LF0;
4KZF;
4GYN;
4GYL;
4CYY;
4CYG;
4CYF;
3SZG;
3SYT;
3SEZ;
3SEQ;
3SDB;
3H0R;
3H0M;
3H0L;
3DLA;
3A2P;
2UXY;
2PLQ;
2G5I;
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References
External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.1.4 |
| BRENDA Enzyme Link: | BRENDA 3.5.1.4 |
| KEGG Enzyme Link: | KEGG3.5.1.4 |
| BioCyc Enzyme Link: | BioCyc 3.5.1.4 |
| ExPASy Enzyme Link: | ExPASy3.5.1.4 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.1.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.1.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.1.4 |
| IntEnz Enzyme Link: | IntEnz 3.5.1.4 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.1.4 |
| RHEA:45048 | acetamide + H2O = acetate + NH4(+) |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[*:3])-[NH2;+0:4].[OH2;+0:5]>>[*:1]=[C;H0;+0:2](-[*:3])-[OH;+0:5].[NH3;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning and sequencing of the gene which encodes the highly inducible acetamidase of Mycobacterium smegmatis. | Mahenthiralingam E, Draper P, Davis EO, Colston MJ | 1993 Mar | 8473863 |
| RHEA:34371 | H2O + indole-3-acetamide = (indol-3-yl)acetate + NH4(+) |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[*:3])-[NH2;+0:4].[OH2;+0:5]>>[*:1]=[C;H0;+0:2](-[*:3])-[OH;+0:5].[NH3;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
| RHEA:12020 | a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[NH2;+0:4].[OH2;+0:5]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:5].[NH3;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The fate of certain organic acids and amides in the rabbit. 7. An amidase of rabbit liver. | Bray HG, James SP, Raffan IM, Ryman BE, Thorpe WV | 1949 | 16748573 |
| The fate of certain organic acids and amides in the rabbit; further observations on the hydrolysis of amides by tissue extracts. | BRAY HG, JAMES SP, THORPE JW, WASDELL MR | 1950 Sep | 14800883 |