EC number:3.5.1.89
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.1 In linear amides |
| ID: | 3.5.1.89 |
|---|---|
| Description: | N-acetylglucosaminylphosphatidylinositol deacetylase. |
| Alternative Name: |
N-acetylglucosaminylphosphatidylinositol de-N-acetylase. N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase. GlcNAc-PI deacetylase. GlcNAc-PI de-N-acetylase. Acetylglucosaminylphosphatidylinositol deacetylase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.1.89 |
| BRENDA Enzyme Link: | BRENDA 3.5.1.89 |
| KEGG Enzyme Link: | KEGG3.5.1.89 |
| BioCyc Enzyme Link: | BioCyc 3.5.1.89 |
| ExPASy Enzyme Link: | ExPASy3.5.1.89 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.1.89 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.1.89 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.1.89 |
| IntEnz Enzyme Link: | IntEnz 3.5.1.89 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.1.89 |
| RHEA:11660 | a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[C;H0;+0:3](=[*:4])-[*:5].[OH2;+0:6]>>[*:1]-[NH2;+0:2].[*:4]=[C;H0;+0:3](-[*:5])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Expression cloning of PIG-L, a candidate N-acetylglucosaminyl-phosphatidylinositol deacetylase. | Nakamura N, Inoue N, Watanabe R, Takahashi M, Takeda J, Stevens VL, Kinoshita T | 1997 Jun 20 | 9188481 |
| Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine. | Doering TL, Masterson WJ, Englund PT, Hart GW | 1989 Jul 5 | 2525555 |
| Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors. | Smith TK, Crossman A, Borissow CN, Paterson MJ, Dix A, Brimacombe JS, Ferguson MA | 2001 Jul 2 | 11432820 |
| Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminylphosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis. | Watanabe R, Ohishi K, Maeda Y, Nakamura N, Kinoshita T | 1999 Apr 1 | 10085243 |