EC number:3.5.1.92

Enzyme

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EC Tree
     3. Hydrolases
        3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
            3.5.1 In linear amides
ID:3.5.1.92
Description:Pantetheine hydrolase.
Alternative Name: Vanin-1.
Pantetheinase.
Prosite: PDOC50263;
PDB:
PDBScop
Cath: 3.60.110.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.5.1.92
BRENDA Enzyme Link: BRENDA 3.5.1.92
KEGG Enzyme Link: KEGG3.5.1.92
BioCyc Enzyme Link: BioCyc 3.5.1.92
ExPASy Enzyme Link: ExPASy3.5.1.92
EC2PDB Enzyme Link: EC2PDB 3.5.1.92
ExplorEnz Enzyme Link: ExplorEnz 3.5.1.92
PRIAM enzyme-specific profiles Link: PRIAM 3.5.1.92
IntEnz Enzyme Link: IntEnz 3.5.1.92
MEDLINE Enzyme Link: MEDLINE 3.5.1.92

EC number:3.5.1.92

MSA:

3.5.1.92;
Phylogenetic Tree:

3.5.1.92;
Uniprot:
M-CSA:
RHEA:13445 (R)-pantetheine + H2O = (R)-pantothenate + cysteamine
RULE(radius=1) [*:1]=[C;H0;+0:2](-[*:3])-[NH;+0:4]-[*:5].[OH2;+0:6]>>[*:5]-[NH2;+0:4].[*:1]=[C;H0;+0:2](-[*:3])-[OH;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes.Martin F, Malergue F, Pitari G, Philippe JM, Philips S, Chabret C, Granjeaud S, Mattei MG, Mungall AJ, Naquet P, Galland F2001 May-Jun11491533
Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice.Pitari G, Malergue F, Martin F, Philippe JM, Massucci MT, Chabret C, Maras B, Duprè S, Naquet P, Galland F2000 Oct 2011042271
Is pantetheinase the actual identity of mouse and human vanin-1 proteins?Maras B, Barra D, Duprè S, Pitari G1999 Nov 1910567687