EC number:3.5.1.93
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.1 In linear amides |
| ID: | 3.5.1.93 |
|---|---|
| Description: | Glutaryl-7-aminocephalosporanic-acid acylase. |
| Alternative Name: |
Glutaryl-7-aminocephalosporanic acid acylase. Glutaryl-7-ACA acylase. GL-7-ACA acylase. GCA. GA. Cephalosporin C acylase. Cephalosporin acylase. CA. 7-beta-(4-carboxybutanamido)cephalosporanic acid acylase. |
| Cath: | 1.10.1400.10; 1.10.439.10; 3.60.20.10; 2.30.120.10; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.1.93 |
| BRENDA Enzyme Link: | BRENDA 3.5.1.93 |
| KEGG Enzyme Link: | KEGG3.5.1.93 |
| BioCyc Enzyme Link: | BioCyc 3.5.1.93 |
| ExPASy Enzyme Link: | ExPASy3.5.1.93 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.1.93 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.1.93 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.1.93 |
| IntEnz Enzyme Link: | IntEnz 3.5.1.93 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.1.93 |
| RHEA:23508 | (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[C;H0;+0:3](=[*:4])-[*:5].[OH2;+0:6]>>[*:1]-[NH2;+0:2].[*:4]=[C;H0;+0:3](-[*:5])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular cloning and structure of the gene for 7 beta-(4-carboxybutanamido)cephalosporanic acid acylase from a Pseudomonas strain. | Matsuda A, Komatsu KI | 1985 Sep | 2993240 |
| Crystal structures of glutaryl 7-aminocephalosporanic acid acylase: insight into autoproteolytic activation. | Kim JK, Yang IS, Rhee S, Dauter Z, Lee YS, Park SS, Kim KH | 2003 Apr 15 | 12680762 |
| Affinity alkylation of the Trp-B4 residue of the beta -subunit of the glutaryl 7-aminocephalosporanic acid acylase of Pseudomonas sp. 130. | Huang X, Zeng R, Ding X, Mao X, Ding Y, Rao Z, Xie Y, Jiang W, Zhao G | 2002 Mar 22 | 11782466 |
| The 2.0 A crystal structure of cephalosporin acylase. | Kim Y, Yoon K, Khang Y, Turley S, Hol WG | 2000 Oct 15 | 11080627 |
| Characterization of an industrial biocatalyst: immobilized glutaryl-7-ACA acylase. | Monti D, Carrea G, Riva S, Baldaro E, Frare G | 2000 Oct 20 | 10972935 |