EC number:3.5.1.99
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.1 In linear amides |
| ID: | 3.5.1.99 | ||
|---|---|---|---|
| Description: | Fatty acid amide hydrolase. | ||
| Alternative Name: |
Oleamide hydrolase. Anandamide amidohydrolase. | ||
| Prosite: | PDOC00494; | ||
| PDB: |
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| Cath: | 3.90.1300.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.1.99 |
| BRENDA Enzyme Link: | BRENDA 3.5.1.99 |
| KEGG Enzyme Link: | KEGG3.5.1.99 |
| BioCyc Enzyme Link: | BioCyc 3.5.1.99 |
| ExPASy Enzyme Link: | ExPASy3.5.1.99 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.1.99 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.1.99 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.1.99 |
| IntEnz Enzyme Link: | IntEnz 3.5.1.99 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.1.99 |
| RHEA:26506 | H2O + oleamide = (9Z)-octadecenoate + NH4(+) |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[*:3])-[NH2;+0:4].[OH2;+0:5]>>[*:1]=[C;H0;+0:2](-[*:3])-[OH;+0:5].[NH3;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization. | Patricelli MP, Lashuel HA, Giang DK, Kelly JW, Cravatt BF | 1998 Oct 27 | 9790682 |
| A second fatty acid amide hydrolase with variable distribution among placental mammals. | Wei BQ, Mikkelsen TS, McKinney MK, Lander ES, Cravatt BF | 2006 Dec 1 | 17015445 |
| Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase. | Patricelli MP, Cravatt BF | 2001 May 22 | 11352748 |
| Fatty acid amide hydrolase substrate specificity. | Boger DL, Fecik RA, Patterson JE, Miyauchi H, Patricelli MP, Cravatt BF | 2000 Dec 4 | 11128635 |
| RHEA:26136 | H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[*:3])-[NH;+0:4]-[*:5].[OH2;+0:6]>>[*:5]-[NH2;+0:4].[*:1]=[C;H0;+0:2](-[*:3])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. | Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA, Gilula NB | 1996 Nov 7 | 8900284 |
| Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase. | Vila A, Rosengarth A, Piomelli D, Cravatt B, Marnett LJ | 2007 Aug 21 | 17649977 |
| A second fatty acid amide hydrolase with variable distribution among placental mammals. | Wei BQ, Mikkelsen TS, McKinney MK, Lander ES, Cravatt BF | 2006 Dec 1 | 17015445 |
| Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase. | McKinney MK, Cravatt BF | 2003 Sep 26 | 12734197 |
| Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. | Bracey MH, Hanson MA, Masuda KR, Stevens RC, Cravatt BF | 2002 Nov 29 | 12459591 |