EC number:3.5.2.12
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.2 In cyclic amides |
| ID: | 3.5.2.12 | ||
|---|---|---|---|
| Description: | 6-aminohexanoate-cyclic-dimer hydrolase. | ||
| Prosite: | PDOC00494; | ||
| PDB: |
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| Cath: | 1.20.5.1730; 3.40.710.10; 3.90.1300.10; 1.20.58.710; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.2.12 |
| BRENDA Enzyme Link: | BRENDA 3.5.2.12 |
| KEGG Enzyme Link: | KEGG3.5.2.12 |
| BioCyc Enzyme Link: | BioCyc 3.5.2.12 |
| ExPASy Enzyme Link: | ExPASy3.5.2.12 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.2.12 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.2.12 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.2.12 |
| IntEnz Enzyme Link: | IntEnz 3.5.2.12 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.2.12 |
| RHEA:16225 | 1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate |
| RULE(radius=1) | ([*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6])>>[*:1]-[NH;+0:2]-[C;H0;+0:4](=[*:3])-[*:5].[OH2;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| 6-Aminohexanoic acid cyclic dimer hydrolase. A new cyclic amide hydrolase produced by Achromobacter guttatus KI74. | Kinoshita S, Negoro S, Muramatsu M, Bisaria VS, Sawada S, Okada H | 1977 Nov 1 | 923591 |
| X-ray crystallographic analysis of the 6-aminohexanoate cyclic dimer hydrolase: catalytic mechanism and evolution of an enzyme responsible for nylon-6 byproduct degradation. | Yasuhira K, Shibata N, Mongami G, Uedo Y, Atsumi Y, Kawashima Y, Hibino A, Tanaka Y, Lee YH, Kato D, Takeo M, Higuchi Y, Negoro S | 2010 Jan 8 | 19889645 |