EC number:3.5.2.9

Enzyme

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     3. Hydrolases
        3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
            3.5.2 In cyclic amides
ID:3.5.2.9
Description:5-oxoprolinase (ATP-hydrolyzing).
Alternative Name: Pyroglutamase (ATP-hydrolyzing).
5-oxo-L-prolinase.
5-OPase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.5.2.9
BRENDA Enzyme Link: BRENDA 3.5.2.9
KEGG Enzyme Link: KEGG3.5.2.9
BioCyc Enzyme Link: BioCyc 3.5.2.9
ExPASy Enzyme Link: ExPASy3.5.2.9
EC2PDB Enzyme Link: EC2PDB 3.5.2.9
ExplorEnz Enzyme Link: ExplorEnz 3.5.2.9
PRIAM enzyme-specific profiles Link: PRIAM 3.5.2.9
IntEnz Enzyme Link: IntEnz 3.5.2.9
MEDLINE Enzyme Link: MEDLINE 3.5.2.9

EC number:3.5.2.9

MSA:

3.5.2.9;
Phylogenetic Tree:

3.5.2.9;
Uniprot:
M-CSA:
RHEA:10348 5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate
RULE(radius=1) [*:1]-[NH;+0:2]-[C;H0;+0:3](=[*:4])-[*:5].[*:6]=[P;H0;+0:7](-[*:8])(-[*:9])-[O;H0;+0:10]-[*:11].[OH2;+0:12].[OH2;+0:13]>>([*:1]-[NH2;+0:2].[*:4]=[C;H0;+0:3](-[*:5])-[OH;+0:13]).[*:11]-[OH;+0:10].[*:6]=[P;H0;+0:7](-[*:8])(-[*:9])-[OH;+0:12]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Enzymatic conversion of 5-oxo-L-proline (L-pyrrolidone carboxylate) to L-glutamate coupled with cleavage of adenosine triphosphate to adenosine diphosphate, a reaction in the -glutamyl cycle.Van der Werf P, Orlowski M, Meister A1971 Dec5289242
OXP1/YKL215c encodes an ATP-dependent 5-oxoprolinase in Saccharomyces cerevisiae: functional characterization, domain structure and identification of actin-like ATP-binding motifs in eukaryotic 5-oxoprolinases.Kumar A, Bachhawat AK2010 Jun20402795