EC number:3.5.3.18
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.3 In linear amidines |
| ID: | 3.5.3.18 |
|---|---|
| Description: | Dimethylargininase. |
| Alternative Name: |
N(G),N(G)-dimethylarginine dimethylaminohydrolase. Dimethylarginine dimethylaminohydrolase. |
| Cath: | 3.75.10.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.3.18 |
| BRENDA Enzyme Link: | BRENDA 3.5.3.18 |
| KEGG Enzyme Link: | KEGG3.5.3.18 |
| BioCyc Enzyme Link: | BioCyc 3.5.3.18 |
| ExPASy Enzyme Link: | ExPASy3.5.3.18 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.3.18 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.3.18 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.3.18 |
| IntEnz Enzyme Link: | IntEnz 3.5.3.18 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.3.18 |
| RHEA:25173 | H2O + N(omega)-methyl-L-arginine = L-citrulline + methylamine |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[C;H0;+0:3](-[*:4])=[NH;+0:5].[OH2;+0:6]>>[*:4]-[C;H0;+0:3](-[NH2;+0:5])=[O;H0;+0:6].[*:1]-[NH2;+0:2] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of dimethylargininase from bovine brain: evidence for a zinc binding site. | Bogumil R, Knipp M, Fundel SM, Vasák M | 1998 Apr 7 | 9537995 |
| RHEA:17305 | H2O + N(omega),N(omega)-dimethyl-L-arginine = dimethylamine + L-citrulline |
| RULE(radius=1) | [*:1]-[N;H0;+0:2](-[*:3])-[C;H0;+0:4](-[*:5])=[NH;+0:6].[OH2;+0:7]>>[*:5]-[C;H0;+0:4](-[NH2;+0:6])=[O;H0;+0:7].[*:1]-[NH;+0:2]-[*:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of dimethylargininase from bovine brain: evidence for a zinc binding site. | Bogumil R, Knipp M, Fundel SM, Vasák M | 1998 Apr 7 | 9537995 |
| Purification and properties of a new enzyme, NG,NG-dimethylarginine dimethylaminohydrolase, from rat kidney. | Ogawa T, Kimoto M, Sasaoka K | 1989 Jun 15 | 2722865 |
| Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide. | Wang Y, Monzingo AF, Hu S, Schaller TH, Robertus JD, Fast W | 2009 Sep 15 | 19663506 |
| Mechanism of 4-HNE mediated inhibition of hDDAH-1: implications in no regulation. | Forbes SP, Druhan LJ, Guzman JE, Parinandi N, Zhang L, Green-Church KB, Cardounel AJ | 2008 Feb 12 | 18171027 |
| Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases. | Leiper JM, Santa Maria J, Chubb A, MacAllister RJ, Charles IG, Whitley GS, Vallance P | 1999 Oct 1 | 10493931 |