EC number:3.5.3.22
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.3 In linear amidines |
| ID: | 3.5.3.22 | ||
|---|---|---|---|
| Description: | Proclavaminate amidinohydrolase. | ||
| Alternative Name: |
Proclavaminic acid amidino hydrolase. Proclavaminate amidino hydrolase. PAH. | ||
| Prosite: | PDOC00135; | ||
| PDB: |
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| Cath: | 3.40.800.10; 3.60.130.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.3.22 |
| BRENDA Enzyme Link: | BRENDA 3.5.3.22 |
| KEGG Enzyme Link: | KEGG3.5.3.22 |
| BioCyc Enzyme Link: | BioCyc 3.5.3.22 |
| ExPASy Enzyme Link: | ExPASy3.5.3.22 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.3.22 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.3.22 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.3.22 |
| IntEnz Enzyme Link: | IntEnz 3.5.3.22 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.3.22 |
| RHEA:17001 | amidinoproclavaminate + H2O = proclavaminate + urea |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[C;H0;+0:3](-[*:4])=[NH;+0:5].[OH2;+0:6]>>[*:4]-[C;H0;+0:3](-[NH2;+0:5])=[O;H0;+0:6].[*:1]-[NH2;+0:2] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification, cloning, sequencing, and overexpression of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis. | Wu TK, Busby RW, Houston TA, McIlwaine DB, Egan LA, Townsend CA | 1995 Jul | 7601835 |
| Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis. | Elkins JM, Clifton IJ, Hernández H, Doan LX, Robinson CV, Schofield CJ, Hewitson KS | 2002 Sep 1 | 12020346 |
| New reactions in clavulanic acid biosynthesis. | Townsend CA | 2002 Oct | 12413541 |
| Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional alpha-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities. | Zhou J, Kelly WL, Bachmann BO, Gunsior M, Townsend CA, Solomon EI | 2001 Aug 1 | 11472170 |