EC number:3.5.4.16
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.4 In cyclic amidines |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.4.16 |
| BRENDA Enzyme Link: | BRENDA 3.5.4.16 |
| KEGG Enzyme Link: | KEGG3.5.4.16 |
| BioCyc Enzyme Link: | BioCyc 3.5.4.16 |
| ExPASy Enzyme Link: | ExPASy3.5.4.16 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.4.16 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.4.16 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.4.16 |
| IntEnz Enzyme Link: | IntEnz 3.5.4.16 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.4.16 |
| RHEA:17473 | GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+) |
| RULE(radius=1) | [OH2;+0:1].[OH;+0:2]-[CH;+0:3]1-[*:4]-[*:5]-[O;H0;+0:6]-[CH;+0:7]-1-[n;H0;+0:8]1:[*:9]:[*:10]:[n;H0;+0:11]:[cH;+0:12]:1>>[O;H0;+0:2]=[CH;+0:12]-[OH;+0:1].[OH;+0:6]-[*:5]-[*:4]-[C;H0;+0:3]1=[N;H0;+0:11]-[*:10]:[*:9]-[NH;+0:8]-[CH2;+0:7]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Novel reaction mechanism of GTP cyclohydrolase I. High-resolution X-ray crystallography of Thermus thermophilus HB8 enzyme complexed with a transition state analogue, the 8-oxoguanine derivative. | Tanaka Y, Nakagawa N, Kuramitsu S, Yokoyama S, Masui R | 2005 Sep | 16169877 |
| Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I. | Rebelo J, Auerbach G, Bader G, Bracher A, Nar H, Hösl C, Schramek N, Kaiser J, Bacher A, Huber R, Fischer M | 2003 Feb 14 | 12559918 |