EC number:3.5.4.37
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.4 In cyclic amidines |
| ID: | 3.5.4.37 |
|---|---|
| Description: | Double-stranded RNA adenine deaminase. |
| Alternative Name: |
DsRNA adenosine deaminase. Double-stranded RNA-specific adenosine deaminase. Double-stranded RNA adenosine deaminase. |
| Cath: | 1.10.10.10; 3.30.160.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.4.37 |
| BRENDA Enzyme Link: | BRENDA 3.5.4.37 |
| KEGG Enzyme Link: | KEGG3.5.4.37 |
| BioCyc Enzyme Link: | BioCyc 3.5.4.37 |
| ExPASy Enzyme Link: | ExPASy3.5.4.37 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.4.37 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.4.37 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.4.37 |
| IntEnz Enzyme Link: | IntEnz 3.5.4.37 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.4.37 |
| RHEA:10120 | adenosine in double-stranded RNA + H(+) + H2O = inosine in double-stranded RNA + NH4(+) |
| RULE(radius=1) | [*:1]-[n;H0;+0:2]1:[cH;+0:3]:[n;H0;+0:4]:[c;H0;+0:5]2:[c;H0;+0:6](-[NH2;+0:7]):[n;H0;+0:8]:[cH;+0:9]:[n;H0;+0:10]:[c;H0;+0:11]:2:1.[H+;H0:12].[OH2;+0:13]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[N;H0;+0:4]-[CH;+0:5]2-[C;H0;+0:6](=[O;H0;+0:13])-[N;H0;+0:8]=[CH;+0:9]-[N;H0;+0:10]=[C;H0;+0:11]-2-1.[NH3;+0:7] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification of native and recombinant double-stranded RNA-specific adenosine deaminases. | O'Connell MA, Gerber A, Keegan LP | 1998 May | 9614652 |
| Two forms of human double-stranded RNA-specific editase 1 (hRED1) generated by the insertion of an Alu cassette. | Gerber A, O'Connell MA, Keller W | 1997 May | 9149227 |
| Purification of the Xenopus laevis double-stranded RNA adenosine deaminase. | Hough RF, Bass BL | 1994 Apr 1 | 8144588 |
| Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing. | Kim U, Wang Y, Sanford T, Zeng Y, Nishikura K | 1994 Nov 22 | 7972084 |
| Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase. | Patterson JB, Samuel CE | 1995 Oct | 7565688 |
| Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. | Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL | 2005 Sep 2 | 16141067 |
| Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA. | Cho DS, Yang W, Lee JT, Shiekhattar R, Murray JM, Nishikura K | 2003 May 9 | 12618436 |
| Substrate recognition by ADAR1 and ADAR2. | Wong SK, Sato S, Lazinski DW | 2001 Jun | 11421361 |