Enzyme

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     3. Hydrolases
        3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
            3.5.4 In cyclic amidines
ID:3.5.4.38
Description:Single-stranded DNA cytosine deaminase.
Alternative Name: Activation-induced deaminase.
Activation-induced cytidine deaminase.

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 3.5.4.38
BRENDA Enzyme Link: BRENDA 3.5.4.38
KEGG Enzyme Link: KEGG3.5.4.38
BioCyc Enzyme Link: BioCyc 3.5.4.38
ExPASy Enzyme Link: ExPASy3.5.4.38
EC2PDB Enzyme Link: EC2PDB 3.5.4.38
ExplorEnz Enzyme Link: ExplorEnz 3.5.4.38
PRIAM enzyme-specific profiles Link: PRIAM 3.5.4.38
IntEnz Enzyme Link: IntEnz 3.5.4.38
MEDLINE Enzyme Link: MEDLINE 3.5.4.38
MSA:

3.5.4.38;

Phylogenetic Tree:

3.5.4.38;

Uniprot:
M-CSA:
RHEA:50948 a 2'-deoxycytidine in a single-stranded DNA + H(+) + H2O = a 2'-deoxyuridine in a single-stranded DNA + NH4(+)
RULE(radius=1) [*:1]:[c;H0;+0:2](-[NH2;+0:3]):[n;H0;+0:4]:[*:5].[H+;H0:6].[OH2;+0:7]>>[*:1]:[c;H0;+0:2](=[O;H0;+0:7]):[nH;+0:4]:[*:5].[NH3;+0:3]
Reaction
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References

TitleAuthorsDatePubMed ID
Cloning and expression of activation induced cytidine deaminase from Bos taurus.Verma S, Goldammer T, Aitken R2010 Apr 1519766322
Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G.Furukawa A, Nagata T, Matsugami A, Habu Y, Sugiyama R, Hayashi F, Kobayashi N, Yokoyama S, Takaku H, Katahira M2009 Feb 1819153609
Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications.Holden LG, Prochnow C, Chang YP, Bransteitter R, Chelico L, Sen U, Stevens RC, Goodman MF, Chen XS2008 Nov 618849968
Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G.Chen KM, Harjes E, Gross PJ, Fahmy A, Lu Y, Shindo K, Harris RS, Matsuo H2008 Mar 618288108
Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID.Larijani M, Martin A2007 Dec17893327
Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Brar SS, Sacho EJ, Tessmer I, Croteau DL, Erie DA, Diaz M2008 Jan 117889624
AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner.Larijani M, Petrov AP, Kolenchenko O, Berru M, Krylov SN, Martin A2007 Jan17060445
The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA.Zhang H, Yang B, Pomerantz RJ, Zhang C, Arunachalam SC, Gao L2003 Jul 312808465
Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations.Sohail A, Klapacz J, Samaranayake M, Ullah A, Bhagwat AS2003 Jun 1512799424