EC number:3.5.4.39

Enzyme

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EC Tree
     3. Hydrolases
        3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
            3.5.4 In cyclic amidines
ID:3.5.4.39
Description:GTP cyclohydrolase IV.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.5.4.39
BRENDA Enzyme Link: BRENDA 3.5.4.39
KEGG Enzyme Link: KEGG3.5.4.39
BioCyc Enzyme Link: BioCyc 3.5.4.39
ExPASy Enzyme Link: ExPASy3.5.4.39
EC2PDB Enzyme Link: EC2PDB 3.5.4.39
ExplorEnz Enzyme Link: ExplorEnz 3.5.4.39
PRIAM enzyme-specific profiles Link: PRIAM 3.5.4.39
IntEnz Enzyme Link: IntEnz 3.5.4.39
MEDLINE Enzyme Link: MEDLINE 3.5.4.39

EC number:3.5.4.39

MSA:

3.5.4.39;
Phylogenetic Tree:

3.5.4.39;
Uniprot:
M-CSA:
RHEA:25860 GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)
RULE(radius=1) ([*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]=[c;H0;+0:8](:[nH;+0:9]:[*:10]):[c;H0;+0:11]1:[*:12]:[n;H0;+0:13](-[CH;+0:14]2-[O;H0;+0:15]-[*:16]-[*:17]-[CH;+0:18]-2-[OH;+0:19]):[cH;+0:20]:[n;H0;+0:21]:1).[OH2;+0:22]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:15]-[*:16]-[*:17]-[C;H0;+0:18]1=[N;H0;+0:21]-[c;H0;+0:11](:[c;H0;+0:20](=[O;H0;+0:19]):[nH;+0:9]:[*:10]):[*:12]-[NH;+0:13]-[CH2;+0:14]-1.[*:7]=[CH;+0:8]-[OH;+0:22]
Reaction
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References

TitleAuthorsDatePubMed ID
Characterization of an Fe(2+)-dependent archaeal-specific GTP cyclohydrolase, MptA, from Methanocaldococcus jannaschii.Grochowski LL, Xu H, Leung K, White RH2007 Jun 517497938