EC number:3.5.4.40
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.4 In cyclic amidines |
| ID: | 3.5.4.40 |
|---|---|
| Description: | Aminodeoxyfutalosine deaminase. |
| Alternative Name: |
Aminofutalosine deaminase. AFL deaminase. |
| Cath: | 3.20.20.140; 2.30.40.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.4.40 |
| BRENDA Enzyme Link: | BRENDA 3.5.4.40 |
| KEGG Enzyme Link: | KEGG3.5.4.40 |
| BioCyc Enzyme Link: | BioCyc 3.5.4.40 |
| ExPASy Enzyme Link: | ExPASy3.5.4.40 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.4.40 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.4.40 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.4.40 |
| IntEnz Enzyme Link: | IntEnz 3.5.4.40 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.4.40 |
| RHEA:40075 | 6-amino-6-deoxyfutalosine + H(+) + H2O = futalosine + NH4(+) |
| RULE(radius=1) | [*:1]:[c;H0;+0:2](-[NH2;+0:3]):[n;H0;+0:4]:[*:5].[H+;H0:6].[OH2;+0:7]>>[*:1]:[c;H0;+0:2](=[O;H0;+0:7]):[nH;+0:4]:[*:5].[NH3;+0:3] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Deamination of 6-aminodeoxyfutalosine in menaquinone biosynthesis by distantly related enzymes. | Goble AM, Toro R, Li X, Ornelas A, Fan H, Eswaramoorthy S, Patskovsky Y, Hillerich B, Seidel R, Sali A, Shoichet BK, Almo SC, Swaminathan S, Tanner ME, Raushel FM | 2013 Sep 17 | 23972005 |
| Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical SAM enzyme. | Mahanta N, Fedoseyenko D, Dairi T, Begley TP | 2013 Oct 16 | 24083939 |
| Diversity of the early step of the futalosine pathway. | Arakawa C, Kuratsu M, Furihata K, Hiratsuka T, Itoh N, Seto H, Dairi T | 2011 Feb | 21098241 |